Obesity as a major risk factor for cancer.
Obesity as a major risk factor for cancer.
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DOI：
10.1155/2013/291546
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发表时间：
2013
影响因子：
3.3
通讯作者：
Silvestris F
中科院分区：
文献类型：
--
作者：
De Pergola G;Silvestris F
肥胖引起的癌症病例估计为20%，恶性肿瘤的风险增加受到饮食，体重变化和身体脂肪分布以及体力活动的影响。国际癌症研究机构和世界癌症研究基金会（WCRF）的报告显示，最有力的证据表明肥胖与以下癌症类型相关：子宫内膜癌、食管腺癌、结直肠癌、绝经后乳腺癌、前列腺癌和肾癌，而较不常见的恶性肿瘤是白血病、非霍奇金淋巴瘤、多发性骨髓瘤、恶性黑色素瘤和甲状腺肿瘤。为了能够开发新的预防和治疗方法，我们首先必须了解癌症与肥胖之间的潜在过程。四个主要系统已被确定为肥胖症中癌症的潜在生产者：胰岛素、胰岛素样生长因子-I、性类固醇和脂肪因子。已经提出了各种新的候选机制：慢性炎症，氧化应激，肿瘤细胞和周围脂肪细胞之间的串扰，迁移脂肪基质细胞，肥胖诱导的缺氧，共享的遗传易感性，以及免疫功能的功能性失败。在此，我们回顾了肥胖和癌症易感性之间的主要致病联系。
The number of cancer cases caused by being obese is estimated to be 20% with the increased risk of malignancies being influenced by diet, weight change, and body fat distribution together with physical activity. Reports from the International Agency for Research into Cancer and the World Cancer Research Fund (WCRF) have shown that the strongest evidence exists for an association of obesity with the following cancer types: endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal, whereas the less common malignancies are leukemia, non-Hodgkin's lymphoma, multiple myeloma, malignant melanoma, and thyroid tumours. To be able to develop novel methods in prevention and treatment, we first must understand the underlying processes which link cancer to obesity. Four main systems have been identified as potential producers of cancer in obesity: insulin, insulin-like growth factor-I, sex steroids, and adipokines. Various novel candidate mechanisms have been proposed: chronic inflammation, oxidative stress, crosstalk between tumour cells and surrounding adipocytes, migrating adipose stromal cells, obesity-induced hypoxia, shared genetic susceptibility, and the functional defeat of immune function. Herein, we review the major pathogenic links between obesity and susceptibility to cancer.
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影响因子：
5.7
作者：
Bedogni, Barbara;Welford, Scott M.;Broome Powell, Marianne
通讯作者：
Broome Powell, Marianne
影响因子：
2.8
作者：
Cox, Michael E.;Gleave, Martin E.;Pollak, Michael
通讯作者：
Pollak, Michael
DOI：
10.1093/jnci/92.16.1329
发表时间：
2000-08-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Byrne, GJ;Ghellal, A;Bundred, NJ
通讯作者：
Bundred, NJ
影响因子：
4.3
作者：
Dai, Zhe;Xu, Yan-Cheng;Niu, Li
通讯作者：
Niu, Li
DOI：
10.1158/1055-9965.epi-11-0556
发表时间：
2011-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Bellows CF;Zhang Y;Chen J;Frazier ML;Kolonin MG
通讯作者：
Kolonin MG