The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines
The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines
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光化学内化 (PCI) 在纳米药物胞质传递中的潜力
DOI：
10.1002/9780470875780.ch17
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发表时间：
2010
影响因子：
3.5
通讯作者：
P. Selbo
中科院分区：
文献类型：
--
作者：
K. Berg;Anette Weyergang;A. Høgset;P. Selbo
大分子在癌症和其他疾病治疗中的应用正变得越来越重要。分子生物学和生物技术的最新进展使改进细胞毒剂或DNA复合体的靶向和设计用于临床应用成为可能。具有治疗潜力的大分子包括用于治疗癌症和其他适应症的核糖体失活蛋白毒素等蛋白质，用于细胞表面靶向的抗体和生长因子，用于疫苗接种的多肽和信使核糖核酸，用于基因治疗的非病毒和病毒载体的DNA，以及用于基因沉默的寡核苷酸(反义寡核苷酸、核酶、多肽核酸(PNA)和用于基因沉默的siRNA)和用于药物输送的纳米颗粒[1]。这些分子在到达靶细胞、进入细胞和达到细胞内治疗靶点之前，需要克服许多细胞外和细胞内的障碍。血清酶的降解和网状内皮系统(RES)细胞的清除，穿透到靶组织
Utilization of macromolecules in the therapy of cancer and other diseases is becoming increasingly important. Recent advances in molecular biology and biotechnology have made it possible to improve targeting and design of cytotoxic agents or DNA complexes for clinical applications. Macromolecules with therapeutic potential include proteins such as ribosome-inactivating protein toxins for treatment of cancer and other indications, antibodies and growth factors for cell surface targeting, peptides and mRNA for vaccination, DNA utilizing nonviral and viral vectors for gene therapy, and oligonucleotides (antisense oligonucleotides, ribozymes, peptide nucleic acids (PNAs), and siRNA for gene silencing) and nanoparticles for drug delivery [1]. There are many extracellular and intracellular barriers for these molecules to overcome before they can arrive at the target cells, enter the cell, and reach intracellular therapeutic targets. Degradation by serum enzymes and elimination by cells of the reticuloendothelial system (RES), penetration into the target tissues
影响因子：
6.5
作者：
ANDERSON, RR;MARGOLIS, RJ;DOVER, JS
通讯作者：
DOVER, JS