Sleep duration in midlife and later life in relation to cognition.
Sleep duration in midlife and later life in relation to cognition.
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DOI：
10.1111/jgs.12790
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发表时间：
2014-06
影响因子：
6.3
通讯作者：
Schernhammer ES
中科院分区：
文献类型：
--
作者：
Devore EE;Grodstein F;Duffy JF;Stampfer MJ;Czeisler CA;Schernhammer ES
睡眠可能会影响老年人的大脑健康;然而，这方面的流行病学研究有限。我们评估了中年和晚年的睡眠时间，以及睡眠时间随时间的变化与老年妇女认知功能的关系。参与者在1986年和2000年报告了睡眠时间，一组老年参与者在1995-2001年开始进行认知测试;随访测试进行了三次，间隔两年。准护士健康研究队列。15，385名女性护士，年龄≥70岁，在初始认知评估时无卒中和抑郁。经验证的基于电话的认知电池来测量认知功能;我们在六年的时间内对四次重复评估进行平均，以估计老年人的整体认知，并评估随访期间认知变化的轨迹。晚年的极端睡眠持续时间与更差的平均认知相关（对于所有六项认知测试的平均整体得分，二次项的p值<0.001）。例如，睡眠时间≤5小时/天的女性比睡眠时间7小时/天的女性的整体认知能力更差，睡眠时间≥9小时/天的女性也是如此;差异相当于增加近两岁。中年人睡眠时间的相关性相似，尽管略有减弱。此外，随着时间的推移，睡眠持续时间变化≥2小时/天的女性比睡眠持续时间没有变化的女性认知更差（例如，对于整体得分，二次项的p值<0.001）。睡眠时间与女性六年来认知功能的轨迹无关（即，认知下降），这可能是由于检测认知下降的随访时间相对较短。中年和晚年的极端睡眠持续时间，以及睡眠持续时间随时间的极端变化，似乎与老年妇女的认知状况恶化有关。
Sleep might influence brain health in older adults; however, epidemiologic research in this area is limited. We evaluated associations of sleep duration at midlife and later life, and change in sleep duration over time, with cognitive function in older women. Participants reported sleep duration in 1986 and 2000, and a subgroup of older participants began cognitive testing in 1995–2001; follow-up testing was conducted three times, at two-year intervals. Prospective Nurses’ Health Study cohort. 15,385 female nurses, aged ≥70 years, free of stroke and depression at the initial cognitive assessment. Validated, telephone-based cognitive battery to measure cognitive function; we averaged the four repeated assessments over a six-year period to estimate overall cognition at older ages, and also evaluated trajectories of cognitive change over follow up. Extreme sleep durations in later life were associated with worse average cognition (p-value for the quadratic term<0.001 for a global score averaging all six cognitive tests). For example, women sleeping ≤5 hours/day had worse global cognition than those sleeping 7 hours/day, as did women sleeping ≥9 hours/day; differences were equivalent to nearly two additional years of age. Associations were similar, though slightly attenuated, for sleep duration in midlife. Also, women whose sleep duration changed by ≥2 hours/day over time had worse cognition than women with no change in sleep duration (e.g., for the global score, p-value for the quadratic term<0.001). Sleep duration was not associated with women’s trajectories of cognitive function over six years (i.e., cognitive decline), which might be attributable to relatively short follow up for detecting cognitive decline. Extreme sleep durations at both midlife and later life, and extreme changes in sleep duration over time, appear to be associated with worse cognitive status in older women.
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影响因子：
4.8
作者：
Keage, Hannah Amy Dianne;Banks, Siobhan;Matthews, Fiona Elaine
通讯作者：
Matthews, Fiona Elaine
DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
影响因子：
5.7
作者：
Lopez, Oscar L;Kuller, Lewis H
通讯作者：
Kuller, Lewis H
影响因子：
14.5
作者：
BADDELEY, AD;BRESSI, S;SPINNLER, H
通讯作者：
SPINNLER, H