Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis.
Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis.
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DOI：
10.2337/dc09-1124
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发表时间：
2010-02
期刊：
影响因子：
16.2
通讯作者：
Miller MA
中科院分区：
文献类型：
--
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
评估习惯性睡眠障碍与2型糖尿病发病率之间的关系，并获得风险的估计。我们使用MEDLINE（1955 - 2009年4月）、EMBASE和Cochrane图书馆对出版物进行了系统检索，并进行了无语言限制的人工检索。我们纳入了前瞻性研究，随访10 - 30年，评估基线睡眠障碍和2型糖尿病发病率。我们为每项研究记录了几个特征。我们提取了睡眠的数量和质量，如何评估它们，并用不同的验证方法定义事件病例。我们提取了相对危险度（RRs）和95% CI，并使用随机效应模型汇总了它们。我们进行敏感性分析，评估异质性和发表偏倚。我们纳入了10项研究（13个独立队列样本，107,756名男性和女性参与者，随访4.2-32年，3,586例2型糖尿病病例）。在综合分析中，睡眠的数量和质量可以预测患2型糖尿病的风险。对于短时间睡眠（≤5-6小时/晚），RR为1.28 (95% CI 1.03-1.60, P = 0.024，异质性P = 0.015)；长时间睡眠组（8 ~ 9小时/夜）的RR为1.48 (1.13 ~ 1.96,P = 0.005)；入睡困难的RR为1.57 (1.25 ~ 1.97,P < 0.0001)；维持睡眠困难的RR为1.84 （1.39 ~ 2.43,P < 0.0001）。睡眠的数量和质量持续且显著地预测2型糖尿病发展的风险。这种关系背后的机制在短睡眠者和长睡眠者之间可能有所不同。
To assess the relationship between habitual sleep disturbances and the incidence of type 2 diabetes and to obtain an estimate of the risk. We conducted a systematic search of publications using MEDLINE (1955–April 2009), EMBASE, and the Cochrane Library and manual searches without language restrictions. We included studies if they were prospective with follow-up >3 years and had an assessment of sleep disturbances at baseline and incidence of type 2 diabetes. We recorded several characteristics for each study. We extracted quantity and quality of sleep, how they were assessed, and incident cases defined with different validated methods. We extracted relative risks (RRs) and 95% CI and pooled them using random-effects models. We performed sensitivity analysis and assessed heterogeneity and publication bias. We included 10 studies (13 independent cohort samples; 107,756 male and female participants, follow-up range 4.2–32 years, and 3,586 incident cases of type 2 diabetes). In pooled analyses, quantity and quality of sleep predicted the risk of development of type 2 diabetes. For short duration of sleep (≤5–6 h/night), the RR was 1.28 (95% CI 1.03–1.60, P = 0.024, heterogeneity P = 0.015); for long duration of sleep (>8–9 h/night), the RR was 1.48 (1.13–1.96, P = 0.005); for difficulty in initiating sleep, the RR was 1.57 (1.25–1.97, P < 0.0001); and for difficulty in maintaining sleep, the RR was 1.84 (1.39–2.43, P < 0.0001). Quantity and quality of sleep consistently and significantly predict the risk of the development of type 2 diabetes. The mechanisms underlying this relation may differ between short and long sleepers.
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影响因子：
4.5
作者：
Hayashino Y;Fukuhara S;Suzukamo Y;Okamura T;Tanaka T;Ueshima H;HIPOP-OHP Research group
通讯作者：
HIPOP-OHP Research group
影响因子：
8.2
作者：
Meisinger, C;Heier, M;Loewel, H
通讯作者：
Loewel, H
影响因子：
5.6
作者：
Meisinger, Christa;Heier, Margit;Doering, Angela
通讯作者：
Doering, Angela
影响因子：
8.3
作者：
Cappuccio, Francesco P.;Stranges, Saverio;Marmot, Michael G.
通讯作者：
Marmot, Michael G.
影响因子：
6.3
作者：
Downs, SH;Black, N
通讯作者：
Black, N