Swallowing dysfunction in cancer patients.
Swallowing dysfunction in cancer patients.
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DOI：
10.1007/s00520-011-1342-2
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发表时间：
2012-03
影响因子：
3.1
通讯作者：
Spijkervet, Fred K. L.
中科院分区：
文献类型：
--
作者：
Raber-Durlacher, Judith E.;Brennan, Mike T.;Leeuw, Irma M. Verdonck-de;Gibson, Rachel J.;Eilers, June G.;Waltimo, Tuomas;Bots, Casper P.;Michelet, Marisol;Sollecito, Thomas P.;Rouleau, Tanya S.;Sewnaik, Aniel;Bensadoun, Rene-Jean;Fliedner, Monica C.;Silverman, Sol, Jr.;Spijkervet, Fred K. L.
关键词：
吞咽困难（吞咽功能障碍）是癌症患者中一种可能被低估的衰弱、抑郁和潜在危及生命的并发症。本文旨在回顾1990年至2010年期间有关吞咽困难的文献，重点是评估工具、患病率、并发症以及对各种不同癌症患者生活质量的影响，特别是对接受头颈部癌症根治性放化疗的患者。文献检索仅限于英文，包括MEDLINE/PubMed和EMBASE。检索的重点是报告吞咽困难是癌症和癌症治疗的副作用的论文。我们通过初步文献检索和参考文献中识别的文章识别了相关文献。确定了广泛的吞咽困难评估工具。吞咽困难与许多因素有关，如肿瘤的直接影响、癌症切除、化疗和放疗，以及与更新的疗法如表皮生长因子受体抑制剂有关。伴随的口腔并发症（如口干症）可能加重主观吞咽困难。大多数文献集中在头颈部癌症，但吞咽困难在其他类型的癌症中也很常见。吞咽障碍是多种癌症患者的临床相关急性和长期并发症。需要更多关于吞咽困难的病程以及在各种治疗方式（包括靶向治疗）后从基线到长期随访对生活质量的影响的前瞻性研究。
Dysphagia (swallowing dysfunction) is a debilitating, depressing, and potentially life-threatening complication in cancer patients that is likely underreported. The present paper is aimed to review relevant dysphagia literature between 1990 and 2010 with a focus on assessment tools, prevalence, complications, and impact on quality of life in patients with a variety of different cancers, particularly in those treated with curative chemoradiation for head and neck cancer. The literature search was limited to the English language and included both MEDLINE/PubMed and EMBASE. The search focused on papers reporting dysphagia as a side effect of cancer and cancer therapy. We identified relevant literature through the primary literature search and by articles identified in references. A wide range of assessment tools for dysphagia was identified. Dysphagia is related to a number of factors such as direct impact of the tumor, cancer resection, chemotherapy, and radiotherapy and to newer therapies such as epidermal growth factor receptor inhibitors. Concomitant oral complications such as xerostomia may exacerbate subjective dysphagia. Most literature focuses on head and neck cancer, but dysphagia is also common in other types of cancer. Swallowing impairment is a clinically relevant acute and long-term complication in patients with a wide variety of cancers. More prospective studies on the course of dysphagia and impact on quality of life from baseline to long-term follow-up after various treatment modalities, including targeted therapies, are needed.
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DOI：
10.1016/s0360-3016(02)02712-8
发表时间：
2002-05-01
影响因子：
7
作者：
Eisbruch, A;Lyden, T;Wolf, GT
通讯作者：
Wolf, GT
影响因子：
3.5
作者：
CELLA, DF;WIKLUND, I;AARONSON, NK
通讯作者：
AARONSON, NK
影响因子：
1.4
作者：
Denk, DM;Swoboda, H;Eibenberger, K
通讯作者：
Eibenberger, K
影响因子：
17.3
作者：
Camidge, DR
通讯作者：
Camidge, DR
影响因子：
45.3
作者：
Curran, Desmond;Giralt, Jordi;Bonner, James A.
通讯作者：
Bonner, James A.