Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men.
Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men.
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在非肥胖的日本男性中，在75克口服葡萄糖耐受性测试期间，与1-H血浆葡萄糖水平升高有关的特征。
DOI：
10.1111/jdi.13245
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发表时间：
2020-11
影响因子：
3.2
通讯作者：
Watada H
中科院分区：
文献类型：
--
作者：
Sato M;Tamura Y;Someya Y;Takeno K;Kaga H;Kadowaki S;Sugimoto D;Kakehi S;Funayama T;Furukawa Y;Suzuki R;Nakagata T;Nishitani-Yokoyama M;Shimada K;Daida H;Aoki S;Sato H;Kawamori R;Watada H
口服葡萄糖耐量试验期间1小时血糖升高（1h-PG; ≥155 mg/dL）是2型糖尿病的风险因素。然而，1h-PG升高的非肥胖亚洲人的代谢特征尚不清楚。因此，我们研究了59名葡萄糖耐量正常的非肥胖日本男性。我们将研究参与者分为低1h-PG组（<155 mg/dL）和高1h-PG组（≥155 mg/dL）。我们比较了各组的代谢特征，包括使用两步高胰岛素-正葡萄糖钳夹法测量的组织特异性胰岛素敏感性。高1h-PG组的胰岛素生成指数和脂联素水平显著低于低1h-PG组。其他特征，包括胰岛素敏感性、肥胖和异位脂肪堆积，在两组之间相似。总之，具有高1h-PG的非肥胖日本男性具有受损的早期胰岛素分泌和较低的脂联素水平。胰岛素抵抗和脂肪分布异常在该人群中不明显。1小时血糖升高的非肥胖亚洲人的特征未知。1小时血糖升高的个体具有较低的胰岛素生成指数和脂联素。低和高1小时血糖组之间的胰岛素敏感性相似。
Elevated 1‐h plasma glucose (1h‐PG; ≥155 mg/dL) during an oral glucose tolerance test is a risk factor for type 2 diabetes. However, the metabolic characteristics of non‐obese Asians with elevated 1h‐PG are unknown. Thus, we studied 59 non‐obese Japanese men with normal glucose tolerance. We divided study participants into the Low 1h‐PG group (<155 mg/dL) and the High 1h‐PG group (≥155 mg/dL). We compared the metabolic characteristics of the groups, including tissue‐specific insulin sensitivity measured using a two‐step hyperinsulinemic‐euglycemic clamp. Insulinogenic index and adiponectin levels were significantly lower in the High 1h‐PG group than in the Low 1h‐PG group. Other characteristics, including insulin sensitivity, adiposity and ectopic fat accumulation, were similar between the groups. In conclusion, non‐obese Japanese men with high 1h‐PG have impaired early‐phase insulin secretion and lower adiponectin levels. Insulin resistance and abnormal fat distribution were not evident in this population. Characteristics of non‐obese Asians with elevated 1‐h plasma glucose are unknown. Individuals with elevated 1‐h plasma glucose have lower insulinogenic index and adiponectin. Insulin sensitivity was similar between the low and high 1‐h plasma glucose groups.
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影响因子：
16.2
作者：
Hsu WC;Araneta MR;Kanaya AM;Chiang JL;Fujimoto W
通讯作者：
Fujimoto W
影响因子：
4.6
作者：
Kaga H;Tamura Y;Takeno K;Kakehi S;Funayama T;Furukawa Y;Nishitani-Yokoyama M;Shimada K;Daida H;Aoki S;Giacca A;Kanazawa A;Kawamori R;Watada H
通讯作者：
Watada H
影响因子：
2
作者：
Uchino, H;Niwa, M;Kawamori, R
通讯作者：
Kawamori, R
影响因子：
16.2
作者：
Pareek, Manan;Bhatt, Deepak L.;Olsen, Michael H.
通讯作者：
Olsen, Michael H.
影响因子：
5.8
作者：
Sato, Fumihiko;Tamura, Yoshifumi;Kawamori, Ryuzo
通讯作者：
Kawamori, Ryuzo