Real-world data on microsatellite instability status in various unresectable or metastatic solid tumors.
Real-world data on microsatellite instability status in various unresectable or metastatic solid tumors.
复制标题
各种不可切除或转移性实体瘤微卫星不稳定性状态的真实世界数据。
DOI：
10.1111/cas.14798
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发表时间：
2021-03
期刊：
影响因子：
5.7
通讯作者：
Yoshino T
中科院分区：
文献类型：
--
作者：
Akagi K;Oki E;Taniguchi H;Nakatani K;Aoki D;Kuwata T;Yoshino T
微卫星不稳定性高（MSI H）是预测免疫检查点抑制剂（ICI）对晚期实体瘤影响的重要生物标志物。微卫星不稳定性-高在各种癌症中检测到，但其频率因癌症类型和阶段而异。因此，计划ICI治疗需要精确的频率。在这项研究中，MSI测试实际上在临床实践中进行的结果进行了调查。在2018年12月至2019年11月期间，共检查了26469份各种癌症样本，以确定是否需要程序性细胞死亡-1阻断。其中26237例（99.1%）获得MSI检测结果。男女比例为51：49，平均年龄为64.3岁。在所有样本中，MSI-H的总体频率为3.72%。按性别划分，女性患者的MSI‐H频率（4.75%）高于男性患者（2.62%; P < .001）。年龄比较显示，年龄小于40岁（6.12%）和80岁或以上（5.77%）的患者的MSI‐H频率显著高于年龄在60至79岁之间的患者（3.09%; P < .001）。在30种癌症类型中检测到微卫星不稳定性高。常见的癌症类型有：子宫内膜癌16.85%，小肠癌8.63%，胃癌6.74%，十二指肠癌5.60%，结直肠癌3.78%。在来自各种器官的癌症中检测到微卫星不稳定性高。MSI-H的频率因癌症类型和发病年龄而异。在考虑ICI治疗时，这些数据应证明特别有用。在这项研究中，我们提供了各种不可切除或转移性实体瘤中微卫星不稳定状态的真实的世界数据，以确定是否适用帕博利珠单抗治疗。
Microsatellite instability‐high (MSI‐H) is an important biomarker for predicting the effect of immune checkpoint inhibitors (ICIs) on advanced solid tumors. Microsatellite instability‐high is detected in various cancers, but its frequency varies by cancer type and stage. Therefore, precise frequency is required to plan ICI therapy. In this study, the results of MSI tests actually carried out in clinical practice were investigated. In total, 26 469 samples of various cancers were examined between December 2018 and November 2019 to determine whether programmed cell death‐1 blockade was indicated. The results of MSI tests were obtained for 26 237 (99.1%) of these samples. The male : female ratio was 51:49 and mean age was 64.3 years. In all samples, the overall frequency of MSI‐H was 3.72%. By gender, the frequency of MSI‐H was higher in female patients (4.75%) than in male patients (2.62%; P < .001). A comparison by age revealed that the frequency of MSI‐H was significantly higher in patients younger than 40 years of age (6.12%) and 80 years or older (5.77%) than in patients aged between 60 and 79 years (3.09%; P < .001). Microsatellite instability‐high was detected in 30 cancer types. Common cancer types were: endometrial cancer, 16.85%; small intestinal cancer, 8.63%; gastric cancer, 6.74%; duodenal cancer, 5.60%; and colorectal cancer, 3.78%. Microsatellite instability‐high was detected in cancer derived from a wide variety of organs. The frequency of MSI‐H varied by cancer type and onset age. These data should prove especially useful when considering ICI treatment. In this study, we presented real‐world data on microsatellite instability status in various unresectable or metastatic solid tumors to determine if pembrolizumab treatment was indicated.
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各种不可切除或转移性实体瘤微卫星不稳定性状态的真实世界数据。
影响因子：
5.7
作者：
Akagi K;Oki E;Taniguchi H;Nakatani K;Aoki D;Kuwata T;Yoshino T
通讯作者：
Yoshino T
影响因子：
4
作者：
Fujiyoshi K;Yamaguchi T;Kakuta M;Takahashi A;Arai Y;Yamada M;Yamamoto G;Ohde S;Takao M;Horiguchi SI;Natsume S;Kazama S;Nishizawa Y;Nishimura Y;Akagi Y;Sakamoto H;Akagi K
通讯作者：
Akagi K
影响因子：
5.7
作者：
Bando, Hideaki;Okamoto, Wataru;Yoshino, Takayuki
通讯作者：
Yoshino, Takayuki
影响因子：
7.5
作者：
Pasanen, Annukka;Loukovaara, Mikko;Butzow, Ralf
通讯作者：
Butzow, Ralf
影响因子：
45.3
作者：
Latham, Alicia;Srinivasan, Preethi;Stadler, Zsofia K.
通讯作者：
Stadler, Zsofia K.