Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel.
Hypothalamic remodeling of thyroid hormone signaling during hibernation in the arctic ground squirrel.
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DOI：
10.1038/s42003-022-03431-8
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发表时间：
2022-05-23
影响因子：
5.9
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中科院分区：
文献类型：
--
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冬眠包括长时间的深度代谢抑制，周期性地被短暂的唤醒打断，其功能尚不清楚。哺乳动物的年周期是由下丘脑伸长细胞中的光敏调节的甲状腺激素依赖性机制计时的，由结节部（PT）中的促甲状腺激素（TSH）驱动，其调节局部TH转化脱碘酶并触发神经内分泌通路的重塑。我们证明，在冬眠过程中，在连续的黑暗中，北极地松鼠（Urocitellus parryii）上调逆行TSH/脱碘酶/TH通路，重塑下丘脑伸长细胞，并激活生殖轴。迫使提前终止冬眠的温暖动物诱导下丘脑脱碘酶的表达和分泌颗粒的PT促甲状腺激素细胞和垂体促性腺激素细胞的积累，但没有进一步激活生殖轴。我们认为，周期性唤醒可能允许短暂激活下丘脑甲状腺激素信号，细胞重塑和重新编程的大脑回路，为短暂的北极夏季做准备。在黑暗中冬眠的北极地松鼠激活结节部-下丘脑甲状腺激素信号通路，重塑下丘脑伸长细胞，并激活生殖轴。
Hibernation involves prolonged intervals of profound metabolic suppression periodically interrupted by brief arousals to euthermy, the function of which is unknown. Annual cycles in mammals are timed by a photoperiodically-regulated thyroid-hormone-dependent mechanism in hypothalamic tanycytes, driven by thyrotropin (TSH) in the pars tuberalis (PT), which regulates local TH-converting deiodinases and triggers remodeling of neuroendocrine pathways. We demonstrate that over the course of hibernation in continuous darkness, arctic ground squirrels (Urocitellus parryii) up-regulate the retrograde TSH/Deiodinase/TH pathway, remodel hypothalamic tanycytes, and activate the reproductive axis. Forcing the premature termination of hibernation by warming animals induced hypothalamic deiodinase expression and the accumulation of secretory granules in PT thyrotrophs and pituitary gonadotrophs, but did not further activate the reproductive axis. We suggest that periodic arousals may allow for the transient activation of hypothalamic thyroid hormone signaling, cellular remodeling, and re-programming of brain circuits in preparation for the short Arctic summer. Arctic ground squirrels hibernating in darkness activate the pars tuberalis - hypothalamus thyroid hormone signaling pathway, remodel hypothalamic tanycytes, and activate the reproductive axis.
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影响因子：
4.1
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2.5
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