Applying simulated in vivo motions to measure human knee and ACL kinetics.
Applying simulated in vivo motions to measure human knee and ACL kinetics.
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DOI：
10.1007/s10439-011-0500-5
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发表时间：
2012-07
影响因子：
3.8
通讯作者：
Shearn, Jason T.
中科院分区：
文献类型：
--
作者：
Herfat, Safa T.;Boguszewski, Daniel V.;Shearn, Jason T.
患者经常经历前交叉韧带（ACL）损伤，但目前的ACL重建策略不能恢复膝关节的原生生物力学，这可能导致骨关节炎的长期早期发作。为了设计更有效的治疗方法，研究人员必须首先了解多种日常生活活动（ADL）的正常体内膝关节功能。虽然已经针对各种ADL测量了人类膝关节的3D运动学，但是3D动力学不能在体内直接测量。或者，可以通过使用机器人技术模拟受试者特定的体内关节运动并将其应用于关节，在动物模型中测量膝关节及其结构的3D动力学。然而，应首先建立合适的生物力学替代物。本研究旨在将模拟人体体内运动应用于人体膝关节，以测量人体膝关节和ACL的动力学。为了建立一个可行的生物力学替代品，模拟体内绵羊运动也适用于人类膝关节，以比较人类和绵羊运动产生的载荷。这两个物种的运动在人类膝关节和ACL中产生了相似的动力学。唯一的显著差异是两种输入运动产生的完整膝关节压缩力。
Patients frequently experience anterior cruciate ligament (ACL) injuries but current ACL reconstruction strategies do not restore the native biomechanics of the knee, which can contribute to the early onset of osteoarthritis in the long term. To design more effective treatments, investigators must first understand normal in vivo knee function for multiple activities of daily living (ADLs). While the 3D kinematics of the human knee have been measured for various ADLs, the 3D kinetics cannot be directly measured in vivo. Alternatively, the 3D kinetics of the knee and its structures can be measured in an animal model by simulating and applying subject-specific in vivo joint motions to a joint using robotics. However, a suitable biomechanical surrogate should first be established. This study was designed to apply a simulated human in vivo motion to human knees to measure the kinetics of the human knee and ACL. In pursuit of establishing a viable biomechanical surrogate, a simulated in vivo ovine motion was also applied to human knees to compare the loads produced by the human and ovine motions. The motions from the two species produced similar kinetics in the human knee and ACL. The only significant difference was the intact knee compression force produced by the two input motions.
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影响因子：
2.4
作者：
MORRISON, JB
通讯作者：
MORRISON, JB
DOI：
10.1097/01.blo.0000144585.65450.d2
发表时间：
2004-10-01
影响因子：
4.2
作者：
Butler, DL;Shearn, JT;Hunter, SA
通讯作者：
Hunter, SA
DOI：
10.1115/1.4003322
发表时间：
2011-02-01
影响因子：
1.7
作者：
Herfat, Safa T.;Shearn, Jason T.;Butler, David L.
通讯作者：
Butler, David L.
影响因子：
2.4
作者：
LAFORTUNE, MA;CAVANAGH, PR;KALENAK, A
通讯作者：
KALENAK, A
影响因子：
7
作者：
Oakley, SP;Lassere, MN;Appleyard, RC
通讯作者：
Appleyard, RC