Perfidious synaptic transmission in the guinea-pig auditory brainstem.
Perfidious synaptic transmission in the guinea-pig auditory brainstem.
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DOI：
10.1371/journal.pone.0203712
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Winter IM
中科院分区：
文献类型：
--
作者：
Stasiak A;Sayles M;Winter IM
听觉脑干中“巨大”突触的存在被认为是一种专为编码时间信息而设计的，以支持对音调、频率和声源定位的感知。这些“巨大”突触在耳蜗腹侧核、梯形体内侧核和外侧小网膜腹侧核中都有发现。然而，对沙鼠腹侧耳蜗核的动作电位经常失效的观察，对这些突触作为简单中继的解释提出了挑战。考虑到这些突触的显著性，确定这种现象是沙鼠独有的还是可以在其他物种中观察到是很重要的。在这里，我们研究了豚鼠耳蜗腹侧核和梯形体内侧核中单元的反应，这些单元被认为是神经元在接受“巨大”突触末端时的输出。我们发现，从耳蜗腹侧核细胞记录的动作电位成分在记录自发活动时发生在约60%的spike波形中。在梯形体内侧核中，我们没有发现动作电位失效的证据。在耳蜗腹侧核，动作电位失效改变了丛状细胞输入和输出之间的感受野。此外，行动潜在失败导致“非初级”的时间适应模式。这对于听觉系统的计算模型是很重要的，这些模型通常假设耳蜗腹侧核丛状细胞的反应与它们的“初级样”听觉神经纤维输入非常相似。
The presence of ‘giant’ synapses in the auditory brainstem is thought to be a specialization designed to encode temporal information to support perception of pitch, frequency, and sound-source localisation. These ‘giant’ synapses have been found in the ventral cochlear nucleus, the medial nucleus of the trapezoid body and the ventral nucleus of the lateral lemniscus. An interpretation of these synapses as simple relays has, however, been challenged by the observation in the gerbil that the action potential frequently fails in the ventral cochlear nucleus. Given the prominence of these synapses it is important to establish whether this phenomenon is unique to the gerbil or can be observed in other species. Here we examine the responses of units, thought to be the output of neurons in receipt of ‘giant’ synaptic endings, in the ventral cochlear nucleus and the medial nucleus of the trapezoid body in the guinea pig. We found that failure of the action-potential component, recorded from cells in the ventral cochlear nucleus, occurred in ~60% of spike waveforms when recording spontaneous activity. In the medial nucleus of the trapezoid body, we did not find evidence for action-potential failure. In the ventral cochlear nucleus action-potential failures transform the receptive field between input and output of bushy cells. Additionally, the action-potential failures result in “non-primary-like” temporal-adaptation patterns. This is important for computational models of the auditory system, which commonly assume the responses of ventral cochlear nucleus bushy cells are very similar to their “primary like” auditory-nerve-fibre inputs.
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DOI：
10.1007/978-1-4419-9517-9_5
发表时间：
2012-01-01
期刊：
SYNAPTIC MECHANISMS IN THE AUDITORY SYSTEM
影响因子：
--
作者：
Borst, J. G. G.;Rusu, S. I.
通讯作者：
Rusu, S. I.
影响因子：
2.5
作者：
BLACKBURN, CC;SACHS, MB
通讯作者：
SACHS, MB
影响因子：
7.7
作者：
Keine, Christian;Ruebsamen, Rudolf;Englitz, Bernhard
通讯作者：
Englitz, Bernhard
DOI：
10.1007/s10162-002-2010-5
发表时间：
2003-03-01
影响因子：
2.4
作者：
Kopp-Scheinpflug, C;Lippe, WR;R端bsamen, R
通讯作者：
R端bsamen, R
影响因子：
5.3
作者：
Campagnola, Luke;Manis, Paul B.
通讯作者：
Manis, Paul B.