Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function.
Association of Early Clinical Response to Laser Rejuvenation of Photoaged Skin with Increased Lipid Metabolism and Restoration of Skin Barrier Function.
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DOI：
10.1016/j.jid.2022.07.024
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发表时间：
2023-03
影响因子：
6.5
通讯作者：
Kang, Sewon
中科院分区：
文献类型：
--
作者：
Garza, Luis A.;Sheu, Mary;Kim, Noori;Tsai, Jerry;Cesar, Sabrina S. Alessi;Lee, Jianming;Hawkins, Stacy S.;Chien, Anna L.;Kang, Sewon
Laser resurfacing treatments for photoaged skin have improved dramatically over the past decades, but few studies have examined the molecular mechanisms underlying differences in clinical response. Seventeen white female participants with moderate-severe photoaging received non-ablative fractional laser treatment on the face and forearm once monthly for 6 months. Biopsies for microarray analysis were performed at baseline and 7 days after facial treatment and at baseline and 1, 7, 14, and 29 days after forearm treatment in each participant, resulting in 119 total samples. Participants were stratified into fast (n=11) and slow (n=6) responders based on the presence of clinical improvement after the first treatment. Microarray analysis revealed upregulation of genes associated with matrix metalloproteinases, collagen and extracellular components, TGF-β signaling, dsRNA signaling, and retinoic acid synthesis following treatment that did not differ significantly between fast and slow responders. Cluster and enrichment analyses suggested significantly greater activation of lipid metabolism and keratinocyte differentiation in fast responders, who showed greater upregulation of acyltransferases, fatty acid elongases, fatty acid 2-hydroxylase, fatty acid desaturases, and specific keratins that may contribute to epidermal barrier function. These results create a novel atlas of molecular changes that correlate with improvements in photoaging after laser therapy.
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DOI：
10.18632/aging.101496
发表时间：
2018-07-18
期刊：
Aging
影响因子：
--
作者：
Cho BA;Yoo SK;Seo JS
通讯作者：
Seo JS
人角蛋白：生物学和病理学。
影响因子：
2.3
作者：
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通讯作者：
Langbein, Lutz
影响因子：
--
作者：
GRIFFITHS, CEM;WANG, TS;ELLIS, CN
通讯作者：
ELLIS, CN
影响因子：
6.5
作者：
Lu, B;Jiang, YJ;Feingold, KR
通讯作者：
Feingold, KR
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
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BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y