Features of hepatitis E virus infection in Japan.
Features of hepatitis E virus infection in Japan.
复制标题
日本戊型肝炎病毒感染的特点。
作者：
H. Okamoto;Masaharu Takahashi;T. Nishizawa
戊型肝炎病毒（HEV）是许多发展中国家急性肝炎的主要原因。戊型肝炎病毒主要通过粪-口途径传播，水传播的流行病是戊型肝炎的特征。最近，越来越多的共识是，HEV相关肝炎也发生在工业化国家没有流行地区旅行史的个体中。由于人和猪HEV毒株在遗传上密切相关，因此认为HEV存在人畜共患传播，并且已经证实了猪HEV对黑猩猩的实验性跨种属感染以及人HEV对猪的实验性跨种属感染。本文综述了日本国内HEV感染的临床、流行病学和病毒学特征，日本人和猪HEV株的遗传相关性，以及HEV传播的可能模式，强调在诊断非甲、非乙、非丙病因的急性或暴发性肝炎时应考虑HEV，即使在没有出国旅行的患者中也是如此。
Hepatitis E virus (HEV) is a major cause of acute hepatitis in many developing countries. HEV is transmitted principally by the fecal-oral route, and water-borne epidemics are characteristic of hepatitis E. Recently, there is growing consensus that HEV-associated hepatitis also occurs among individuals in industrialized nations who had no history of travel to endemic areas. Zoonotic spread of HEV has been suggested as human and swine HEV strains are closely related genetically and experimental cross-species infection of swine HEV to a chimpanzee and that of human HEV to swine have been demonstrated. This review describes the clinical, epidemiological and virological characteristics of domestic HEV infection in Japan, the genetic relatedness of Japanese human and swine HEV strains, and possible modes of HEV transmission, emphasizing that HEV should be considered in the diagnosis of acute or fulminant hepatitis of non-A, non-B, non-C etiology, even in patients who have not traveled abroad.
DOI：
10.4269/ajtmh.1999.61.331
发表时间：
1999-08-01
影响因子：
3.3
作者：
Kabrane-Lazizi, Y;Fine, JB;Purcell, RH
通讯作者：
Purcell, RH