The Neuroimmunology of Multiple Sclerosis: Fictions and Facts.
The Neuroimmunology of Multiple Sclerosis: Fictions and Facts.
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DOI：
10.3389/fneur.2021.796378
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发表时间：
2021
影响因子：
3.4
通讯作者：
Pachner AR
中科院分区：
文献类型：
--
作者：
Pachner AR
在过去的五十年里，多发性硬化症的神经免疫学取得了巨大的进步，这导致了临床诊断和治疗的改善。然而，进一步的进展必须考虑到对该领域一些复杂问题的理解，特别是对“事实”和“虚构”的理解。考虑到神经系统和免疫系统的难以置信的复杂性，我们对这种疾病的基本生物学的理解是非常不完整的，这并不奇怪。这种缺乏了解导致了该领域的许多争议。这篇综述确定了一些这些争议和事实/虚构与疾病的基本神经免疫学（细胞和分子），和重要的临床问题。幸运的是，该领域正处于从过度依赖动物模型到更广泛地了解人类疾病的健康过渡中，这可能会导致许多改进的治疗方法，特别是多发性硬化症（MS）中的神经变性。
There have been tremendous advances in the neuroimmunology of multiple sclerosis over the past five decades, which have led to improved diagnosis and therapy in the clinic. However, further advances must take into account an understanding of some of the complex issues in the field, particularly an appreciation of “facts” and “fiction.” Not surprisingly given the incredible complexity of both the nervous and immune systems, our understanding of the basic biology of the disease is very incomplete. This lack of understanding has led to many controversies in the field. This review identifies some of these controversies and facts/fictions with relation to the basic neuroimmunology of the disease (cells and molecules), and important clinical issues. Fortunately, the field is in a healthy transition from excessive reliance on animal models to a broader understanding of the disease in humans, which will likely lead to many improved treatments especially of the neurodegeneration in multiple sclerosis (MS).
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影响因子：
2.5
作者：
Bonnan M
通讯作者：
Bonnan M
影响因子：
5.8
作者：
Cadavid, Diego;Cohen, Jeffrey A.;Mikol, Daniel
通讯作者：
Mikol, Daniel
影响因子：
3.2
作者：
Burgoon, Mark P.;Caldas, Yupanqui A.;Owens, Gregory P.
通讯作者：
Owens, Gregory P.
影响因子：
11.5
作者：
Bar-Or, Amit;Pachner, Andrew;Menguy-Vacheron, Francoise;Kaplan, Johanne;Wiendl, Heinz
通讯作者：
Wiendl, Heinz
DOI：
10.1177/13524585211010070
发表时间：
2021-06
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Schmierer K;Giovannoni G
通讯作者：
Giovannoni G