Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice.
Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice.
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DOI：
10.3389/fimmu.2021.746447
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发表时间：
2021
影响因子：
7.3
通讯作者：
Sun W
中科院分区：
文献类型：
--
作者：
Liu Y;Strohmeier S;González-Domínguez I;Tan J;Simon V;Krammer F;García-Sastre A;Palese P;Sun W
流感病毒在以免疫为主的血凝素(HA)头部区域发生抗原性变化，需要每年重新配制季节性流感病毒疫苗并重新接种，以持续保护。我们以前合成了B型流感病毒的嵌合型HA(MHA)蛋白，通过序贯免疫将免疫反应重定向到HA的免疫劣势保守表位。由于目前约90%的流感病毒疫苗是用灭活病毒平台生产的，我们制备了显示同源(相同的B-HA骨架)或异源(不同的B-HA骨架)嵌合体的灭活乙型流感病毒小鼠。这两种方法都能诱导持久的交叉保护性抗体反应，表现出很强的抗体依赖性细胞毒性(ADCC)活性。我们认为，B病毒MHA候选疫苗代表着朝着通用B型流感病毒疫苗迈出的重要一步。
Influenza viruses undergo antigenic changes in the immuno-dominant hemagglutinin (HA) head domain, necessitating annual re-formulation of and re-vaccination with seasonal influenza virus vaccines for continuing protection. We previously synthesized mosaic HA (mHA) proteins of influenza B viruses which redirect the immune response towards the immuno-subdominant conserved epitopes of the HA via sequential immunization. As ~90% of current influenza virus vaccines are manufactured using the inactivated virus platform, we generated and sequentially vaccinated mice with inactivated influenza B viruses displaying either the homologous (same B HA backbones) or the heterologous (different B HA backbones) mosaic HAs. Both approaches induced long-lasting and cross-protective antibody responses showing strong antibody-dependent cellular cytotoxicity (ADCC) activity. We believe the B virus mHA vaccine candidates represent a major step towards a universal influenza B virus vaccine.
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DOI：
10.1093/cid/ciaa102
发表时间：
2021-04-08
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Gaglani M;Vasudevan A;Raiyani C;Murthy K;Chen W;Reis M;Belongia EA;McLean HQ;Jackson ML;Jackson LA;Zimmerman RK;Nowalk MP;Monto AS;Martin ET;Chung JR;Spencer S;Fry AM;Flannery B
通讯作者：
Flannery B
影响因子：
3.7
作者：
Krammer F;Margine I;Tan GS;Pica N;Krause JC;Palese P
通讯作者：
Palese P
影响因子：
3.7
作者：
Crepey, Pascal;Redondo, Esther;Solozabal, Miriam
通讯作者：
Solozabal, Miriam
影响因子：
5.5
作者：
Beyer, W. E. P.;Palache, A. M.;Osterhaus, A. D. M. E.
通讯作者：
Osterhaus, A. D. M. E.
影响因子：
1.2
作者：
Kaufmann, Lukas;Syedbasha, Mohammedyaseen;Egli, Adrian
通讯作者：
Egli, Adrian