Effectiveness of Trivalent and Quadrivalent Inactivated Vaccines Against Influenza B in the United States, 2011-2012 to 2016-2017.
Effectiveness of Trivalent and Quadrivalent Inactivated Vaccines Against Influenza B in the United States, 2011-2012 to 2016-2017.
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DOI：
10.1093/cid/ciaa102
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发表时间：
2021-04-08
期刊：
影响因子：
--
通讯作者：
Flannery B
中科院分区：
文献类型：
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作者：
Gaglani M;Vasudevan A;Raiyani C;Murthy K;Chen W;Reis M;Belongia EA;McLean HQ;Jackson ML;Jackson LA;Zimmerman RK;Nowalk MP;Monto AS;Martin ET;Chung JR;Spencer S;Fry AM;Flannery B
从2013年开始，在美国，含2种B病毒的四价流感疫苗逐渐取代三价疫苗。我们比较了四价和三价灭活疫苗（分别为IIV4和IIV3）在过渡期（IIV4使用迅速增加）对B型流感疾病的疫苗有效性。美国流感疫苗有效性（Flu VE）网络分析了2011 - 2012年6个流感季期间在发病7天内入组的42600例年龄≥ 6个月的门诊患者中的25019例。 对上呼吸道标本进行流感病毒类型和B谱系检测。使用逻辑回归，我们通过比较接种疫苗与未接种疫苗的受试者中总体B型流感感染的几率和B谱系的几率来估计IIV4或IIV3的有效性。在2013 - 2014年的4个季节中，我们比较了IIV4与IIV3接种者感染B型流感的相对几率。在6个季节中的4个季节，三价疫苗包括主要的循环B谱系。在广泛使用IIV4和IIV3的4个流感季节期间，IIV4对任何B型流感的总体有效性为53%（95%置信区间[CI]，45 - 59），IIV3为45%（95% CI，34 - 54）。IIV4比IIV3更有效地对抗IIV3中不包括的B谱系，但是对抗任何与流感B相关的疾病的比较有效性都不支持两种疫苗效价。尽管四价灭活流感疫苗对增加的B病毒谱系的有效性更高，但四价灭活流感疫苗的接种与增强对任何B流感疾病的保护无关。需要在全球范围内进行公共卫生影响和成本效益分析。在2013 - 2014年开始的4个流感季节期间，三价和四价灭活流感疫苗在美国对任何B流感疾病提供了等效的保护，而四价疫苗对增加的B病毒谱系提供了更好的保护。
Since 2013, quadrivalent influenza vaccines containing 2 B viruses gradually replaced trivalent vaccines in the United States. We compared the vaccine effectiveness of quadrivalent to trivalent inactivated vaccines (IIV4 to IIV3, respectively) against illness due to influenza B during the transition, when IIV4 use increased rapidly. The US Influenza Vaccine Effectiveness (Flu VE) Network analyzed 25 019 of 42 600 outpatients aged ≥6 months who enrolled within 7 days of illness onset during 6 seasons from 2011–2012. Upper respiratory specimens were tested for the influenza virus type and B lineage. Using logistic regression, we estimated IIV4 or IIV3 effectiveness by comparing the odds of an influenza B infection overall and the odds of B lineage among vaccinated versus unvaccinated participants. Over 4 seasons from 2013–2014, we compared the relative odds of an influenza B infection among IIV4 versus IIV3 recipients. Trivalent vaccines included the predominantly circulating B lineage in 4 of 6 seasons. During 4 influenza seasons when both IIV4 and IIV3 were widely used, the overall effectiveness against any influenza B was 53% (95% confidence interval [CI], 45–59) for IIV4 versus 45% (95% CI, 34–54) for IIV3. IIV4 was more effective than IIV3 against the B lineage not included in IIV3, but comparative effectiveness against illnesses related to any influenza B favored neither vaccine valency. The uptake of quadrivalent inactivated influenza vaccines was not associated with increased protection against any influenza B illness, despite the higher effectiveness of quadrivalent vaccines against the added B virus lineage. Public health impact and cost-benefit analyses are needed globally. During the 4 influenza seasons beginning in 2013–2014, trivalent and quadrivalent inactivated influenza vaccines provided equivalent protection against any influenza B illness in the United States, while quadrivalent vaccines provided better protection against the added B virus lineage.
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DOI：
10.15585/mmwr.mm6722a4
发表时间：
2018-06-08
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garten R;Blanton L;Elal AIA;Alabi N;Barnes J;Biggerstaff M;Brammer L;Budd AP;Burns E;Cummings CN;Davis T;Garg S;Gubareva L;Jang Y;Kniss K;Kramer N;Lindstrom S;Mustaquim D;O'Halloran A;Sessions W;Taylor C;Xu X;Dugan VG;Fry AM;Wentworth DE;Katz J;Jernigan D
通讯作者：
Jernigan D
影响因子：
5.4
作者：
McCullers, JA;Saito, T;Iverson, AR
通讯作者：
Iverson, AR
影响因子：
11.8
作者：
Flannery, Brendan;Chung, Jessie R.;Barnes, John
通讯作者：
Barnes, John
影响因子：
5.5
作者：
Camilloni, B.;Neri, M.;Iorio, A. M.
通讯作者：
Iorio, A. M.
影响因子：
33.9
作者：
Blanton, Lenee;Alabi, Noreen;Brammer, Lynnette
通讯作者：
Brammer, Lynnette