Flavivirus Receptors: Diversity, Identity, and Cell Entry.

Flavivirus Receptors: Diversity, Identity, and Cell Entry.
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DOI:
10.3389/fimmu.2018.02180
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发表时间:
2018
影响因子:
7.3
通讯作者:
Kedzierski L
Kedzierski L
中科院分区:
医学2区
文献类型:
--
作者:
Laureti M;Narayanan D;Rodriguez-Andres J;Fazakerley JK;Kedzierski L

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黄病毒是新出现和重新出现的节肢动物传播的病原体,在全世界范围内造成显着的死亡率和发病率。该属由 70 多种小型、正义、单链 RNA 病毒组成,它们导致一系列人类和动物疾病,症状从轻微的流感样感染到致命的脑炎和出血热。尽管该属的基因组和结构相似,但不同黄病毒的感染会导致不同的临床表现。本综述重点关注两种出血性黄病毒:登革热病毒和黄热病病毒,以及两种嗜神经性黄病毒:日本脑炎病毒和寨卡病毒。我们回顾了当前关于宿主-病原体相互作用、病毒进入策略和向性的知识。
Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than seventy small, positive-sense, single-stranded RNA viruses, which are responsible for a spectrum of human and animal diseases ranging in symptoms from mild, influenza-like infection to fatal encephalitis and haemorrhagic fever. Despite genomic and structural similarities across the genus, infections by different flaviviruses result in disparate clinical presentations. This review focusses on two haemorrhagic flaviviruses, dengue virus and yellow fever virus, and two neurotropic flaviviruses, Japanese encephalitis virus and Zika virus. We review current knowledge on host-pathogen interactions, virus entry strategies and tropism.
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