Prefrontal pathways target excitatory and inhibitory systems in memory-related medial temporal cortices.
Prefrontal pathways target excitatory and inhibitory systems in memory-related medial temporal cortices.
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DOI：
10.1016/j.neuroimage.2011.01.064
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发表时间：
2011-04-15
期刊：
影响因子：
5.7
通讯作者：
Barbas, Helen
中科院分区：
文献类型：
--
作者：
Bunce, Jamie G.;Barbas, Helen
关键词：
前扣带回皮质(ACC)位于内侧前额叶皮质的尾侧部分，参与监测与先前学习结果的记忆有关的持续行为。ACC信息如何与内侧颞叶(MTL)记忆系统相互作用尚不清楚。本研究采用多层次的方法研究了猕猴ACC与海马旁皮质之间的相互作用：1)ACC投射到海马旁皮质的突触前特征是什么？2)该通路的突触后靶点是什么？局部兴奋和抑制系统的神经支配是否存在板层差异？标记的Acc终末在海马区TH和Tf被量化，聚类分析表明，突起的大小各不相同，小的(≤0.97μm)和大的(>；0.97Gm)终末几乎均匀地分布在上层和深层。详尽的采样和无偏倚的体视学技术独立地表明，在海马旁皮质的皮质层中，小的和大的突起大致均匀地分布。电子显微镜(EM)对该通路的突触分析表明，虽然大多数ACC投射与兴奋性神经元形成突触，但相当大比例(23%)的投射针对假定的抑制性类别，偏爱小白蛋白(PV+)抑制性神经元。这些发现表明，突触机制可能有助于整合与注意力和记忆相关的信号。
The anterior cingulate cortex (ACC), situated in the caudal part of the medial prefrontal cortex, is involved in monitoring on-going behavior pertaining to memory of previously learned outcomes. How ACC information interacts with the medial temporal lobe (MTL) memory system is not well understood. The present study used a multitiered approach to address two questions on the interactions between the ACC and the parahippocampal cortices in the rhesus monkey: 1) What are the presynaptic characteristics of ACC projections to the parahippocampal cortices? 2) What are the postsynaptic targets of the pathway and are there laminar differences in innervation of local excitatory and inhibitory systems? Labeled ACC terminations were quantified in parahippocampal areas TH and TF and a cluster analysis showed that boutons varied in size, with a population of small (≤ 0.97 μm) and large (>0.97 μm) terminations that were nearly evenly distributed in the upper and deep layers. Exhaustive sampling as well as unbiased stereological techniques independently showed that small and large boutons were about evenly distributed within cortical layers in the parahippocampal cortex. Synaptic analysis of the pathway, performed at the electron microscope (EM) showed that while most of the ACC projections formed synapses with excitatory neurons, a significant proportion (23%) targeted presumed inhibitory classes with a preference for parvalbumin (PV+) inhibitory neurons. These findings suggest synaptic mechanisms that may help integrate signals associated with attention and memory.
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影响因子：
3.5
作者：
Barbas, H;Blatt, GJ
通讯作者：
Blatt, GJ
DOI：
10.1073/pnas.0809511105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Borgers, Christoph;Epstein, Steven;Kopell, Nancy J.
通讯作者：
Kopell, Nancy J.
影响因子：
2.4
作者：
Barbas H;Saha S;Rempel-Clower N;Ghashghaei T
通讯作者：
Ghashghaei T
影响因子：
3.4
作者：
Apergis-Schoute, John;Pinto, Aline;Pare, Denis
通讯作者：
Pare, Denis
影响因子：
2.5
作者：
Blatt, GJ;Pandya, DN;Rosene, DL
通讯作者：
Rosene, DL