Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases.
Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases.
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DOI：
10.1016/j.pharmthera.2016.03.018
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发表时间：
2016-07
影响因子：
13.5
通讯作者：
Hong JT
中科院分区：
文献类型：
--
作者：
Park MH;Jo M;Kim YR;Lee CK;Hong JT
过氧化物还原酶（Peroxiredoxins，PRDXs）是一种抗氧化酶，能催化过氧化物还原，平衡细胞内过氧化氢（H2O2）水平，是细胞信号传导和代谢所必需的，也是氧化还原信号传导的调节剂。氧化还原信号传导是细胞信号传导途径的重要组成部分，参与细胞生长、代谢、激素信号传导、免疫调节和各种其他生理功能的调节。早期研究表明PRDXs调节细胞生长、代谢和免疫调节，因此参与多种癌症、神经退行性疾病和炎性疾病的病理调节剂或保护剂。氧化应激和抗氧化系统是氧化还原信号调节疾病的重要调节因子。此外，已经证明基于硫醇的氧化还原系统通过过氧化物酶调节几种氧化还原依赖性过程相关的疾病。在这篇综述文章中，我们将讨论有关PRDXs在疾病发展中的最新发现，并进一步讨论针对PRDXs的治疗方法。此外，我们将建议PRDXs可能是几种疾病的靶点，靶向PRDXs的治疗剂可能对治疗癌症，神经退行性疾病和炎症性疾病具有潜在的有益作用。未来的研究应该为设计针对PRDXs的新治疗方法开辟新的途径。
Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to balance cellular hydrogen peroxide (H2O2) levels, which are essential for cell signaling and metabolism and act as a regulator of redox signaling. Redox signaling is a critical component of cell signaling pathways that are involved in the regulation of cell growth, metabolism, hormone signaling, immune regulation and variety of other physiological functions. Early studies demonstrated that PRDXs regulates cell growth, metabolism and immune regulation and therefore involved in the pathologic regulator or protectant of several cancers, neurodegenerative diseases and inflammatory diseases. Oxidative stress and antioxidant systems are important regulators of redox signaling regulated diseases. In addition, thiol-based redox systems through peroxiredoxins have been demonstrated to regulate several redox-dependent process related diseases. In this review article, we will discuss recent findings regarding PRDXs in the development of diseases and further discuss therapeutic approaches targeting PRDXs. Moreover, we will suggest that PRDXs could be targets of several diseases and the therapeutic agents for targeting PRDXs may have potential beneficial effects for the treatment of cancers, neurodegenerative diseases and inflammatory diseases. Future research should open new avenues for the design of novel therapeutic approaches targeting PRDXs.
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DOI：
10.1158/1541-7786.mcr-08-0546
发表时间：
2009-09
期刊：
Molecular cancer research : MCR
影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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