Mouse models of neurological disorders: a view from the blood-brain barrier.
Mouse models of neurological disorders: a view from the blood-brain barrier.
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DOI：
10.1016/j.bbadis.2009.10.011
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发表时间：
2010-10
影响因子：
6.2
通讯作者：
Banks, William A.
中科院分区：
文献类型：
--
作者：
Banks, William A.
关键词：
涉及血脑屏障(BBB)失调的疾病模型的数量大大增加。造成这种扩大的主要因素是，已知涉及血脑屏障的疾病的数量增加，血脑屏障的已知功能增加，以及研究这些不同功能的模型和工具的数量增加。在许多情况下，血脑屏障可能是疾病的靶点；目前的想法可能包括高血压脑病和中风。另一类疾病是血脑屏障的特殊属性可能导致疾病；例如，病原体穿越血脑屏障的能力通常取决于病原体在脑内皮细胞或脉络丛细胞中调用细胞转化途径的能力。特别值得注意的是血脑屏障可能是疾病的主要部位或在疾病的发生或发展中起主要作用的疾病。越来越多的疾病被如此分类，其中血脑屏障功能障碍或调节失调起着主要作用；这篇综述强调了血脑屏障的这种作用，包括那些被提议用于阿尔茨海默病和肥胖症的疾病。
The number of disease models that involve an aspect of blood-brain barrier (BBB) dysregulation have increased tremendously. The main factors contributing to this expansion have been an increased number of diseases in which the BBB is known to be involved, an increase in the known functions of the BBB, and an increase in the number of models and tools with which those diverse functions can be studied. In many cases, the BBB may be a target of disease; current thinking would include hypertensive encephalopathy and perhaps stroke in this category. Another category are those diseases in which special attributes of the BBB may predispose to disease; for example, the ability of a pathogen to cross the BBB often depends on the pathogen’s ability to invoke trancytotic pathways in the brain endothelial or choroid plexus cell. Of special interest are those diseases in which the BBB may be the primary seat of disease or play a major role in the onset or progression of the disease. An increasing number of diseases are so categorized in which BBB dysfunction or dysregulation plays a major role; this review highlights such roles for the BBB including those proposed for Alzheimer’s disease and obesity.
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影响因子：
4.8
作者：
Banks, William A.;Dohgu, Shinya;Vo, Than Q.
通讯作者：
Vo, Than Q.
影响因子：
3
作者：
Banks, WA;DiPalma, CR;Farrell, CL
通讯作者：
Farrell, CL
影响因子：
100.3
作者：
Baxter, Alan G.
通讯作者：
Baxter, Alan G.
DOI：
10.1152/ajpendo.00468.2002
发表时间：
2003-07-01
影响因子：
5.1
作者：
Banks, WA;Farrell, CL
通讯作者：
Farrell, CL
影响因子：
4.8
作者：
Ahima, RS;Bjorbæk, C;Flier, JS
通讯作者：
Flier, JS