Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey.
Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey.
复制标题
DOI：
10.1371/journal.pone.0013997
复制
发表时间：
2010-11-16
期刊：
影响因子：
3.7
通讯作者：
Liu F
中科院分区：
文献类型：
--
作者：
Xie X;Ma YT;Yang YN;Fu ZY;Li XM;Huang D;Ma X;Chen BD;Liu F
血清淀粉样蛋白A（SAA）不仅是一种炎症因子，而且是一种载脂蛋白，可以取代载脂蛋白A1（apoA1）成为高密度脂蛋白（HDL）的主要载脂蛋白，与动脉粥样硬化有关。然而，SAA 基因多态性与健康受试者颈总动脉内膜中层厚度 (IMT) 之间的关系仍不清楚。我们在参与心血管风险调查 (CRS) 研究的一组健康受试者中研究了 SAA1 和 SAA2 基因多态性与 IMT 的作用。对来自新疆省（中国西部）七个城市的 1914 名受试者（849 名男性；1065 名女性）进行了颈动脉 IMT 的人体测量和 B 型超声测量。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对4个SNP(rs12218、rs2229338、rs1059559和rs2468844)进行基因分型。通过主导模型（P<0.001）和加性模型（P = 0.003）分析，SNP rs12218与颈动脉IMT相关，且多变量调整后差异仍然显着（分别为P = 0.008、P<0.001）。通过隐性模型分析进行多变量调整后，在 rs2468844 中也观察到了这种关系（P = 0.011），但在多变量调整前后的 rs2229338 和 rs1059559 中没有观察到这种关系。这些关联不会因血清 HDL 浓度而改变。此外，rs2468844 和 rs12218（交互作用 P<0.001）和 rs2229338（交互作用 P = 0.001）之间在颈动脉 IMT 上存在显着的交互作用。 SAA1基因的rs12218和SAA2基因的rs2468844均与健康汉族受试者的颈动脉IMT相关。
Serum amyloid A protein (SAA) is not only an inflammatory factor, but also an apolipoprotein that can replace apolipoprotein A1 (apoA1) as the major apolipoprotein of high-density lipoprotein (HDL), which has been linked to atherosclerosis. However, the relationship between genetic polymorphisms of SAA and the intima-media thickness (IMT) of the common carotid artery in healthy subjects remains unclear. We investigated the role of SAA1 and SAA2 gene polymorphisms with IMT in a cohort of healthy subjects participating in the Cardiovascular Risk Survey (CRS) study. Anthropometric and B-mode ultrasound of the carotid IMT were measured in 1914 subjects (849 men; 1065 women) recruited from seven cities in Xinjiang province, (western China). Four SNPs (rs12218, rs2229338, rs1059559, and rs2468844) were genotyped by use of the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The SNP rs12218 was associated with carotid IMT by analyses of a dominate model (P<0.001) and additive model (P = 0.003), and the difference remained significant after multivariate adjustment (P = 0.008, P<0.001, respectively). This relationship was also observed in rs2468844 after multivariate adjustment by recessive model analysis (P = 0.011) but this was not observed in rs2229338 and rs1059559 before and after multivariate adjustment. These associations were not modified by serum HDL concentration. Furthermore, there were significant interactions between rs2468844 and rs12218 (interaction P<0.001) and rs2229338 (interaction P = 0.001) on carotid IMT. Both rs12218 of the SAA1 gene and rs2468844 of SAA2 gene are associated with carotid IMT in healthy Han Chinese subjects.
登录
查看更多内容
影响因子：
37.8
作者：
Schillinger, M;Exner, M;Minar, E
通讯作者：
Minar, E
影响因子：
37.8
作者：
Johnson, BD;Kip, KE;Reis, SE
通讯作者：
Reis, SE
影响因子：
8.7
作者：
Artl, A;Marsche, G;Malle, E
通讯作者：
Malle, E
DOI：
10.1073/pnas.74.9.4025
发表时间：
1977-01-01
影响因子：
11.1
作者：
BENDITT, EP;ERIKSEN, N
通讯作者：
ERIKSEN, N
影响因子：
4.4
作者：
Carty CL;Heagerty P;Heckbert SR;Enquobahrie DA;Jarvik GP;Davis S;Tracy RP;Reiner AP
通讯作者：
Reiner AP