Perivascular macrophages in the CNS: From health to neurovascular diseases.

Perivascular macrophages in the CNS: From health to neurovascular diseases.
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中枢神经系统血管周围巨噬细胞:从健康到神经血管疾病

DOI:
10.1111/cns.13954
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发表时间:
2022-12
影响因子:
5.5
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
作者:

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脑血管周围巨噬细胞(PVMs)在支持中枢神经系统结构、脑发育和维持生理功能等方面具有多方面的作用,因而受到越来越多的关注。他们还广泛参与神经疾病,如神经退行性变和缺血性中风。此外,据报道,PVM在不同的病理情况下既有有益的影响,也有有害的影响。先进的研究技术使对PVM的进一步深入研究成为可能,并揭示了其起源、分化和调控机制的新概念。加深对PVMs在不同脑组织病理状态中作用的理解,可以揭示新的表型变化和调控信号,这可能为开发针对PVMs的新的治疗策略铺平道路。
Brain perivascular macrophages (PVMs) are attracting increasing attention as this emerging cell population in the brain has multifaced roles in supporting the central nervous system structure, brain development, and maintaining physiological functions. They also widely participate in neurological diseases such as neurodegeneration and ischemic stroke. Moreover, PVMs have been reported to have both beneficial and detrimental effects under different pathological contexts. Advanced research technologies allowed the further in‐depth study of PVMs and revealed novel concepts in their origins, differentiation, and regulatory mechanisms. Deepened understanding of the roles of PVMs in different brain pathological conditions can reveal novel phenotypic changes and regulatory signaling, which might pave the way for the development of novel treatment strategies targeting PVMs.
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发表时间: 2018-04
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影响因子: --
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