Nucleolar stress: Friend or foe in cardiac function?
Nucleolar stress: Friend or foe in cardiac function?
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核仁应激：心脏功能的朋友还是敌人？
DOI：
10.3389/fcvm.2022.1045455
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
过去几十年的研究揭示了核仁在应激反应和人类疾病进展中的新角色。核仁中核糖体生物合成的破坏导致核仁结构和功能的异常，称为核仁应激，通过核仁释放对各种蛋白质的封存来启动应激反应通路。虽然从临床和基础研究中获得的数据已经忠实地证明核仁应激参与了心肌病的发病机制，但关于核仁应激在心脏病进展中的确切作用仍不清楚。一方面，急性心肌损伤后核仁应激的启动导致多种保护心肌的核仁蛋白表达上调，包括核干素(NS)、核磷蛋白(NPM)和核仁蛋白(NCL)。因此，核仁应激在促进心肌细胞的存活和修复中起着重要作用。另一方面，核仁结构和功能的异常与心脏疾病的恶化有关。值得注意的是，晚期缺血性和扩张型心肌病的心肌细胞显示银染核仁组织区(AgNORs)受损和核仁增大，类似于组织老化的特征。总的来说，核仁异常与心脏疾病的发展密切相关。
Studies in the past decades have uncovered an emerging role of the nucleolus in stress response and human disease progression. The disruption of ribosome biogenesis in the nucleolus causes aberrant nucleolar architecture and function, termed nucleolar stress, to initiate stress-responsive pathways via nucleolar release sequestration of various proteins. While data obtained from both clinical and basic investigations have faithfully demonstrated an involvement of nucleolar stress in the pathogenesis of cardiomyopathy, much remains unclear regarding its precise role in the progression of cardiac diseases. On the one hand, the initiation of nucleolar stress following acute myocardial damage leads to the upregulation of various cardioprotective nucleolar proteins, including nucleostemin (NS), nucleophosmin (NPM) and nucleolin (NCL). As a result, nucleolar stress plays an important role in facilitating the survival and repair of cardiomyocytes. On the other hand, abnormalities in nucleolar architecture and function are correlated with the deterioration of cardiac diseases. Notably, the cardiomyocytes of advanced ischemic and dilated cardiomyopathy display impaired silver-stained nucleolar organiser regions (AgNORs) and enlarged nucleoli, resembling the characteristics of tissue aging. Collectively, nucleolar abnormalities are critically involved in the development of cardiac diseases.
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影响因子：
7.8
作者：
D'Aquila P;Montesanto A;Mandalà M;Garasto S;Mari V;Corsonello A;Bellizzi D;Passarino G
通讯作者：
Passarino G
DOI：
10.1016/j.tig.2019.07.011
发表时间：
2019-10
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Cerqueira AV;Lemos B
通讯作者：
Lemos B
影响因子：
8.8
作者：
Harding SM;Boiarsky JA;Greenberg RA
通讯作者：
Greenberg RA
影响因子：
20.1
作者：
Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
14.9
作者：
Chen J;Lobb IT;Morin P;Novo SM;Simpson J;Kennerknecht K;von Kriegsheim A;Batchelor EE;Oakley F;Stark LA
通讯作者：
Stark LA