Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation.
Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation.
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DOI：
10.1111/febs.16101
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
MacGurn JA
中科院分区：
文献类型：
--
作者：
Hepowit NL;Kolbe CC;Zelle SR;Latz E;MacGurn JA
泛素的调节影响是巨大的，包括所有的细胞过程，凭借其在蛋白质降解，膜运输和细胞信号传导的中心作用。但是，泛素，一个76个氨基酸的肽，是如何在真核细胞中执行如此多样，复杂的功能的呢？部分答案源于与泛素聚合物相关的高度复杂性，它可以根据拓扑结构和细胞环境进行不同的“阅读”和处理。然而，最近的证据表明，泛素本身的翻译后修饰增强了泛素密码子的复杂性。在这里，我们回顾了最近的发现有关的泛素编码的磷酸化调节。我们总结了什么是目前已知的磷酸化泛素在Ser65，Ser57和Thr12，我们讨论了潜在的磷酸化调控泛素在其他网站。我们还讨论了越来越多的证据表明，泛素样修饰剂，如SUMO，同样受到磷酸化的调节。要完全理解这些调控代码及其复杂的词汇，需要解剖泛素和泛素样蛋白磷酸化的调控机制，特别是在细胞应激和疾病的背景下。
The regulatory influence of ubiquitin is vast, encompassing all cellular processes, by virtue of its central roles in protein degradation, membrane trafficking, and cell signaling. But how does ubiquitin, a 76 amino acid peptide, carry out such diverse, complex functions in eukaryotic cells? Part of the answer is rooted in the high degree of complexity associated with ubiquitin polymers, which can be “read” and processed differently depending on topology and cellular context. However, recent evidence indicates that post-translational modifications on ubiquitin itself enhance the complexity of the ubiquitin code. Here, we review recent discoveries related to the regulation of the ubiquitin code by phosphorylation. We summarize what is currently known about phosphorylation of ubiquitin at Ser65, Ser57 and Thr12, and we discuss the potential for phospho-regulation of ubiquitin at other sites. We also discuss accumulating evidence that ubiquitin-like modifiers, such as SUMO, are likewise regulated by phosphorylation. A complete understanding of these regulatory codes and their complex lexicon will require dissection of mechanisms that govern phosphorylation of ubiquitin and ubiquitin-like proteins, particularly in the context of cellular stress and disease.
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影响因子：
62.1
作者：
Cappadocia L;Lima CD
通讯作者：
Lima CD
影响因子：
7.3
作者：
Kettenbach AN;Schweppe DK;Faherty BK;Pechenick D;Pletnev AA;Gerber SA
通讯作者：
Gerber SA
影响因子：
64.8
作者：
Ichimura, Y;Kirisako, T;Ohsumi, Y
通讯作者：
Ohsumi, Y
影响因子：
14.9
作者：
Hornbeck PV;Kornhauser JM;Tkachev S;Zhang B;Skrzypek E;Murray B;Latham V;Sullivan M
通讯作者：
Sullivan M
DOI：
10.1083/jcb.201002108
发表时间：
2010-08-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cherra SJ 3rd;Kulich SM;Uechi G;Balasubramani M;Mountzouris J;Day BW;Chu CT
通讯作者：
Chu CT