Country‐specific constancy by age in cagA+ proportion of Helicobacter pylori infections
Country‐specific constancy by age in cagA+ proportion of Helicobacter pylori infections
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cag 中按年龄划分的国家/地区特定一致性幽门螺杆菌感染比例
DOI：
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发表时间：
1997
影响因子：
6.4
通讯作者：
M. Blaser
中科院分区：
文献类型：
--
作者：
G. Perez;Niranjan Bhat;James T Gaensbauer;A. Fraser;David N. Taylor;E. Kuipers;Lian Zhang;W. You;M. Blaser
幽门螺杆菌菌株可能是cagA+或cagA-，在对数研究中，cagA+菌株感染与萎缩性胃炎和远端胃癌的发生风险增加相关。我们试图确定不同地理区域产生CagA菌株的相对比例，以及不同胃癌和食管癌发病率的国家CagA血清阳性率的变化程度。采用酶联免疫吸附试验（ELISA）检测468例无症状H.来自加拿大、秘鲁、中国、泰国、荷兰和新西兰3个不同种族的幽门螺杆菌感染成年人。秘鲁和泰国的CagA血清阳性率（分别为82.2%和78.8%）均显著高于中国（37.9%）、加拿大（41.9%）、荷兰（39.0%）和新西兰（28.2%）受试者，但在每个人群中，各性别和年龄组的比率相对恒定。8个研究人群中报告的胃癌而非食管癌的发病率与H。幽门螺杆菌血清阳性率。CagA阳性率的变化与胃癌或食管癌发病率的变化无显著相关性。我们的数据表明，CagA血清阳性率不是影响胃癌发病率的主要因素。Int. J. Cancer 72：453-456，1997.© 1997 Wiley利斯公司
Helicobacter pylori strains may be either cagA+ or cagA−, and in logitudinal studies, infection with a cagA+ strain has been associated with increased risk for the development of atrophic gastritis and cancer of the distal stomach. We sought to determine the relative proportion of strains producing CagA in different geographic locales, and the extent to which CagA seroprevalence varied in countries with different gastric and esophageal cancer rates. Using an enzyme‐linked immunosorbent assay (ELISA) to detect serum IgG to CagA, we examined sera from 468 asymptomatic H. pylori‐infected adults from Canada, Peru, China, Thailand, The Netherlands and 3 different ethnic groups in New Zealand. The CagA seroprevalence in Peru and Thailand (82.2% and 78.8%, respectively) were each substantially higher than for the Chinese (37.9%), Canadian (41.9%), Dutch (39.0%) and New Zealand (28.2%) subjects, but within each population, rates were relatively constant across gender and age groups. Reported gastric but not esophageal cancer rates for the 8 studied populations were significantly associated with H. pylori seroprevalence. Variation in CagA positivity rates was not significantly associated with variation in either gastric or esophageal cancer rates. Our data suggest that CagA seroprevalence is not the major factor influencing gastric cancer rates. Int. J. Cancer 72:453–456, 1997. © 1997 Wiley‐Liss, Inc.
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影响因子：
11.2
作者：
M. Blaser;G. Perez-Perez-G.-Perez-Perez-82101131;H. Kleanthous;T. Cover;R. Peek;P. Chyou;G. Stemmermann;A. Nomura
通讯作者：
M. Blaser;G. Perez-Perez-G.-Perez-Perez-82101131;H. Kleanthous;T. Cover;R. Peek;P. Chyou;G. Stemmermann;A. Nomura
DOI：
10.1093/jnci/87.23.1777
发表时间：
1995-12-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
KUIPERS, EJ;PEREZPEREZ, GI;BLASER, MJ
通讯作者：
BLASER, MJ
影响因子：
11.2
作者：
M. Blaser;P. Chyou;A. Nomura
通讯作者：
M. Blaser;P. Chyou;A. Nomura
影响因子：
158.5
作者：
PARSONNET, J;FRIEDMAN, GD;SIBLEY, RK
通讯作者：
SIBLEY, RK
影响因子：
158.5
作者：
NOMURA, A;STEMMERMANN, GN;BLASER, MJ
通讯作者：
BLASER, MJ