Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe.
Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe.
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DOI：
10.7554/elife.82850
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发表时间：
2023-08-14
期刊：
影响因子：
7.7
通讯作者：
Palomero-Gallagher N
中科院分区：
文献类型：
--
作者：
Rapan L;Froudist-Walsh S;Niu M;Xu T;Zhao L;Funck T;Wang XJ;Amunts K;Palomero-Gallagher N
基于定量细胞和受体结构分析，我们确定了35个前额叶区，包括新的细分步行者的领域10，9，8B和46。受体密度的统计分析显示，在外侧和腹外侧前额叶皮层的区域差异。事实上，包含46区和12区的亚区的结构和功能组织表明α2受体的区域间水平存在显著差异。此外，多变量分析包括以前确定的16个运动区在同一猕猴大脑的受体指纹，并揭示了5个集群，包括额叶区。我们使用来自非人类灵长类动物数据共享联盟PRIME-DE的MRI数据集，使用所得的额叶地图作为种子区域进行功能连接分析。在一般情况下，嘴部位于额区的特点是较大的指纹，也就是说，更高的受体密度，和更强的区域互连。而更多的尾部区域有较小的指纹，但显示出广泛的连接模式与遥远的皮质区域。总之，这项研究提供了一个全面的洞察大脑皮层的功能组织的分子结构，从而调和灵长类动物额叶的结构和功能的层次组织之间的差异。最后，我们的数据通过EBRAINS和BALSA存储库向整个科学界公开。
Based on quantitative cyto- and receptor architectonic analyses, we identified 35 prefrontal areas, including novel subdivisions of Walker’s areas 10, 9, 8B, and 46. Statistical analysis of receptor densities revealed regional differences in lateral and ventrolateral prefrontal cortex. Indeed, structural and functional organization of subdivisions encompassing areas 46 and 12 demonstrated significant differences in the interareal levels of α2 receptors. Furthermore, multivariate analysis included receptor fingerprints of previously identified 16 motor areas in the same macaque brains and revealed 5 clusters encompassing frontal lobe areas. We used the MRI datasets from the non-human primate data sharing consortium PRIME-DE to perform functional connectivity analyses using the resulting frontal maps as seed regions. In general, rostrally located frontal areas were characterized by bigger fingerprints, that is, higher receptor densities, and stronger regional interconnections. Whereas more caudal areas had smaller fingerprints, but showed a widespread connectivity pattern with distant cortical regions. Taken together, this study provides a comprehensive insight into the molecular structure underlying the functional organization of the cortex and, thus, reconcile the discrepancies between the structural and functional hierarchical organization of the primate frontal lobe. Finally, our data are publicly available via the EBRAINS and BALSA repositories for the entire scientific community.
影响因子：
3
作者：
Moirano JM;Bezgin GY;Ahlers EO;Kötter R;Converse AK
通讯作者：
Converse AK