Rhesus Macaque Brain Atlas Regions Aligned to an MRI Template.
Rhesus Macaque Brain Atlas Regions Aligned to an MRI Template.
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DOI：
10.1007/s12021-018-9400-2
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发表时间：
2019-04
期刊：
影响因子：
3
通讯作者：
Converse AK
中科院分区：
文献类型：
--
作者：
Moirano JM;Bezgin GY;Ahlers EO;Kötter R;Converse AK
为了帮助分析恒河猴脑图像，我们将Paxinos等人广泛使用的图谱中的数字化解剖区域与基于大量受试者的已发表的磁共振成像（MRI）模板进行了比对。将数字标记的图谱图像与模板在2D中对齐，然后在3D中对齐。由此产生的灰质区域似乎在质量上与模板很好地配准。为了定量验证该程序，将20只恒河猴的MR脑图像与模板沿着对齐，其中每个受试者的MRI中的纹状体和皮质区中的区域由手绘制。手绘区域和模板区域之间存在良好的几何重叠。正电子发射断层扫描（PET）图像显示摄取的多巴胺D2受体配体的相同的主题对齐的模板空间，并发现良好的协议之间的示踪剂结合的措施计算使用手绘和模板区域。总之，解剖学定义的一组恒河猴脑区已对准MRI模板，并已验证用于纹状体和皮质区子集的PET成像分析。整个200多个地区的集合可在https://www.nitrc.org/上公开获得。
To aid in the analysis of rhesus macaque brain images, we aligned digitized anatomical regions from the widely used atlas of Paxinos et al. to a published magnetic resonance imaging (MRI) template based on a large number of subjects. Digitally labelled atlas images were aligned to the template in 2D and then in 3D. The resulting grey matter regions appear qualitatively to be well registered to the template. To quantitatively validate the procedure, MR brain images of 20 rhesus macaques were aligned to the template along with regions drawn by hand in striatal and cortical areas in each subject’s MRI. There was good geometric overlap between the hand drawn regions and the template regions. Positron emission tomography (PET) images of the same subjects showing uptake of a dopamine D2 receptor ligand were aligned to the template space, and good agreement was found between tracer binding measures calculated using the hand drawn and template regions. In conclusion, an anatomically defined set of rhesus macaque brain regions has been aligned to an MRI template and has been validated for analysis of PET imaging in a subset of striatal and cortical areas. The entire set of over 200 regions is publicly available at https://www.nitrc.org/.
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