SWItching on epidermal cell fate.

SWItching on epidermal cell fate.
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DOI:
10.1016/j.stem.2013.01.011
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发表时间:
2013-02-07
期刊:
影响因子:
23.9
通讯作者:
Ezhkova, Elena
Ezhkova, Elena
中科院分区:
医学1区
文献类型:
--
作者:
Perdigoto, Carolina N.;Bardot, Evan S.;Ezhkova, Elena

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染色质调节复合物是众所周知的干细胞命运的调节剂;然而,调节其活性的机制还不清楚。在这一期的《细胞干细胞》中,显示ACTL 6a抑制SWI/SNF复合物靶向分化基因,从而保持表皮祖细胞状态。
Chromatin regulatory complexes are well known regulators of stem cell fate; however, the mechanisms regulating their activity are not well understood. In this issue of Cell Stem Cell, show that ACTL6a inhibits targeting of the SWI/SNF complex to differentiation genes, thereby preserving the epidermal progenitor state.
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