Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.
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DOI:
10.1016/j.addr.2011.04.006
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发表时间:
2012-01
影响因子:
16.1
通讯作者:
Au, Jessie L. -S.
Au, Jessie L. -S.
中科院分区:
医学1区
文献类型:
--
作者:
Li, Yinghuan;Wang, Jie;Wientjes, M. Guillaume;Au, Jessie L. -S.

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分子药物的进展导致在细胞和分子水平上鉴定有希望的靶点。这些靶标位于细胞外和细胞内区室中。后者包括细胞质、细胞核、胞浆、高尔基体和内质网。本报告概述了将纳米药物递送到实体瘤内各种靶点的障碍,克服这些障碍的实验方法以及纳米技术的潜在效用。
Advances in molecular medicines have led to identification of promising targets on cellular and molecular levels. These targets are located in extracellular and intracellular compartments. The latter include cytosol, nucleus, mitochondrion, Golgi apparatus and endoplasmic reticulum. This report gives an overview on the barriers to delivering nanomedicines to various target sites within a solid tumor, the experimental approaches to overcome such barriers, and the potential utility of nanotechnology.
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