Positive Surgical Margins in the 10 Most Common Solid Cancers.
Positive Surgical Margins in the 10 Most Common Solid Cancers.
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DOI：
10.1038/s41598-018-23403-5
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发表时间：
2018-04-09
影响因子：
4.6
通讯作者：
Nguyen QT
中科院分区：
文献类型：
--
作者：
Orosco RK;Tapia VJ;Califano JA;Clary B;Cohen EEW;Kane C;Lippman SM;Messer K;Molinolo A;Murphy JD;Pang J;Sacco A;Tringale KR;Wallace A;Nguyen QT
肿瘤切除后的阳性切缘（PSM）通常需要辅助治疗，并具有重要的经济和预后意义。我们试图比较美国10种最常见的实体癌的PSM率，并评估随时间的趋势。从1998年到2012年，在国家癌症数据库中发现了超过1000万例患者，其中650万例有手术切缘数据。比较了1998-2002年和2008-2012年两个时期的PSM比率。PSM与肿瘤类型、分级呈正相关。在女性和男性中，卵巢癌和前列腺癌的PSM患病率分别最高。男女患癌症的PSM率最高的是口腔肿瘤。在研究期间，男性和女性患乳腺癌、肺癌和支气管癌的PSM率都有所下降。膀胱癌、结肠癌、直肠癌、肾癌和肾盂癌的PSM增加。这项大规模的分析评估了PSM在美国的规模，以便将未来的努力集中在改善肿瘤外科护理上，以优化价值和改善患者的预后。
A positive surgical margin (PSM) following cancer resection oftentimes necessitates adjuvant treatments and carries significant financial and prognostic implications. We sought to compare PSM rates for the ten most common solid cancers in the United States, and to assess trends over time. Over 10 million patients were identified in the National Cancer Data Base from 1998–2012, and 6.5 million had surgical margin data. PSM rates were compared between two time periods, 1998–2002 and 2008–2012. PSM was positively correlated with tumor category and grade. Ovarian and prostate cancers had the highest PSM prevalence in women and men, respectively. The highest PSM rates for cancers affecting both genders were seen for oral cavity tumors. PSM rates for breast cancer and lung and bronchus cancer in both men and women declined over the study period. PSM increases were seen for bladder, colon and rectum, and kidney and renal pelvis cancers. This large-scale analysis appraises the magnitude of PSM in the United States in order to focus future efforts on improving oncologic surgical care with the goal of optimizing value and improving patient outcomes.
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影响因子：
3
作者：
ANDERSEN, PE;KINSELLA, J;SHAH, JP
通讯作者：
SHAH, JP
影响因子：
7.2
作者：
DEYO, RA;CHERKIN, DC;CIOL, MA
通讯作者：
CIOL, MA
影响因子：
9.7
作者：
Jacobs, Bruce L.;Zhang, Yun;Hollenbeck, Brent K.
通讯作者：
Hollenbeck, Brent K.
DOI：
10.1016/j.urolonc.2009.09.019
发表时间：
2010-03-01
影响因子：
2.7
作者：
Cookson, Michael S.;Chang, Sam S.
通讯作者：
Chang, Sam S.
影响因子：
2.6
作者：
Hong, Chae Moon;Ahn, Byeong-Cheol;Lee, Jaetae
通讯作者：
Lee, Jaetae