Effects of acute pramipexole on preference for gambling-like schedules of reinforcement in rats.
Effects of acute pramipexole on preference for gambling-like schedules of reinforcement in rats.
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DOI：
10.1007/s00213-010-2006-5
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发表时间：
2011-01
影响因子：
3.4
通讯作者：
Fowler, Stephen C.
中科院分区：
文献类型：
--
作者：
Johnson, Patrick S.;Madden, Gregory J.;Brewer, Adam T.;Pinkston, Jonathan W.;Fowler, Stephen C.
普拉克索和其他直接多巴胺激动剂药物与冲动行为的发展有关，如服用药物控制帕金森病或不宁腿综合征症状的患者的病理性赌博。很少有实验室研究检查普拉克索对赌博样行为的影响。本研究使用接近人类赌博的某些方面的啮齿动物模型来检查急性普拉克索（0.03、0.1、0.18和0.3 mg/kg）对大鼠选择通过完成可变比率（即，类似赌博）或固定比率响应要求。在很少选择可变比例替代品的情况下，除了最低剂量的普拉克索外，所有剂量的普拉克索均显著增加了可变比例替代品的选择（平均比生理盐水高15%）。同样的剂量并没有影响选择显着的控制条件，旨在评估参与非特异性药物的影响。普拉克索增加了启动试验（+ 9.12 s）和强制选择试验（可变比率：+ 0.21 s;固定比率：+ 0.88 s）中开始应答运行的延迟，但不影响应答持续的测量（“停留”的条件概率）。这些发现与将普拉克索与人类赌博增加的表达联系起来的临床报告一致。结果进行了讨论的背景下，神经行为的证据表明，多巴胺受体激动剂增加敏感性奖励延迟和破坏适当的反馈，从负面的结果。
Pramipexole and other direct dopamine agonist medications have been implicated in the development of impulsive behavior such as pathological gambling among those taking the drug to control symptoms of Parkinson’s disease or restless leg syndrome. Few laboratory studies examining pramipexole’s effects on gambling-like behavior have been conducted. The present study used a rodent model approximating some aspects of human gambling to examine within-subject effects of acute pramipexole (0.03, 0.1, 0.18, & 0.3 mg/kg) on rat’s choices to earn food reinforcement by completing variable-ratio (i.e., gambling-like) or fixed-ratio response requirements. In a condition in which the variable-ratio alternative was rarely selected, all but the lowest dose of pramipexole significantly increased choice of the variable-ratio alternative (an average of 15% above saline).. The same doses did not affect choice significantly in a control condition designed to evaluate the involvement of nonspecific drug effects. Pramipexole increased latencies to initiate trials (+ 9.12 s) and to begin response runs on forced-choice trials (variable-ratio: + 0.21 s; fixed-ratio: + 0.88 s), but did not affect measures of response perseveration (conditional probabilities of “staying”). The findings are consistent with clinical reports linking pramipexole to the expression of increased gambling in humans. Results are discussed in the context of neurobehavioral evidence suggesting that dopamine agonists increase sensitivity to reward delay and disrupt appropriate feedback from negative outcomes.
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影响因子：
2.4
作者：
Crockford, David;Quickfall, Jeremy;el-Guebaly, Nady
通讯作者：
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通讯作者：
Robbins, Trevor W.
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作者：
Giovannoni, G;O'Sullivan, JD;Lees, AJL
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Lees, AJL