Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck.
Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck.
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DOI：
10.1111/j.1582-4934.2008.00650.x
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发表时间：
2010-01
影响因子：
5.3
通讯作者：
Rihova B
中科院分区：
文献类型：
--
作者：
Boucek J;Mrkvan T;Chovanec M;Kuchar M;Betka J;Boucek V;Hladikova M;Betka J;Eckschlager T;Rihova B
调节性T细胞(Treg)是抗癌免疫反应的重要调节者，在癌症患者的血液中Treg频率增加。对112例头颈部鳞状细胞癌患者在确诊时采集外周血，分析淋巴细胞亚群(CD3+；CD3CD16+CD56+；−+；CD8+；CD19+；CD4+CD45RA+)、全血计数和肿瘤标志物(鳞癌、癌胚抗原、α-1-抗胰蛋白酶；CyfRA21-1；C反应蛋白)。将数据按TNM分类进行分组，并确定其在治疗结束后1年的病程中的意义。CD8+细胞百分率随肿瘤分级的升高而升高，CD/D8比值随肿瘤分级的升高而降低。B淋巴细胞比例在局部转移患者中下降(11.25%比9.22%)。与对照组(分别为9.0%、38.1%和15.8%)相比，HNSCC患者外周血中Treg(15.2%)和CD4+细胞(45.3%)增加，而NK细胞(11.8%)减少。诊断时获得的数据用于评估肿瘤标志物(SCC、Cyfra 21-1和AAT)在评估预后方面的意义。早期复发患者的红细胞计数(4.64×10~(12)/L比4.45×10~(12)/L)和血红蛋白水平(14.58g/dl比14.05g/dl)降低，Treg计数(8.91%比15.70%)升高。我们的结果表明，检测这些参数有助于预测HNSCC患者的预后，并有助于改进治疗策略。
Regulatory T cells (Treg) are important regulators of anti-cancer immune responses, and an increase in Treg frequency was observed in the blood of cancer patients. Blood samples from 112 patients with head and neck squamous cell carcinoma antigen (HNSCC) were obtained at the time of tumour diagnosis, and lymphocyte subpopulations (CD3+; CD3−CD16+CD56+; CD4+; CD8+; CD19+; CD4+CD45RA+) with emphasis on Treg counts (CD3+CD4+CD25+), complete blood count and tumour markers (squamous cell carcinoma [SCC]; CEA; α-1-antitrypsin [AAT]; Cyfra 21–1; C-reactive protein [CRP]) were analysed. The data were grouped according to TNM classification, and their significance for the course of the disease at an interval of 1 year after the end of the therapy was determined. The percentage of CD8+ cells increased and the CD/D8 ratio decreased with tumour grade. The ratio of B lymphocytes decreased in patients with locoregional metastases (11.25%versus 9.22%). Treg (15.2%) and CD4+ cells (45.3%) increased, while NK cells (11.8%) decreased in HNSCC patients compared to controls (9.0%, 38.1% and 15.8%, respectively). The data obtained at time of diagnosis were used to assess the significance of tumour markers (SCC, Cyfra 21–1 and AAT) for evaluation of prognosis. The erythrocyte counts (4.64 × 1012/l versus 4.45 × 1012/l) and haemoglobin levels (14.58 g/dl versus 14.05 g/dl) decreased, while Treg counts (8.91%versus 15.70%) increased in patients with early recurrence. Our results show that examination of these parameters could be helpful for prognostication in HNSCC patients and aid improvement of treatment strategy.
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影响因子：
11.5
作者：
Badoual, C;Hans, S;Tartour, E
通讯作者：
Tartour, E
影响因子：
11.5
作者：
Kuss, I;Hathaway, B;Whiteside, TL
通讯作者：
Whiteside, TL
影响因子：
45.3
作者：
Molling, Johan W.;Langius, Jacqueline A. E.;van den Eertwegh, Alfons J. M.
通讯作者：
van den Eertwegh, Alfons J. M.
影响因子：
--
作者：
Nestor, Marika;Ekberg, Tomas;Anniko, Matti
通讯作者：
Anniko, Matti
影响因子：
11.2
作者：
Karcher, J;Dyckhoff, G;Herold-Mende, C
通讯作者：
Herold-Mende, C