Calcium and phosphate ion releasing composite: effect of pH on release and mechanical properties.
Calcium and phosphate ion releasing composite: effect of pH on release and mechanical properties.
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DOI：
10.1016/j.dental.2008.10.009
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发表时间：
2009-04
期刊：
影响因子：
5
通讯作者：
Sun, Limin
中科院分区：
文献类型：
--
作者：
Xu, Hockin H. K.;Weir, Michael D.;Sun, Limin
关键词：
继发龋和修复体断裂是牙洞修复面临的两个主要挑战。本研究的目的是开发一种使用磷酸四钙（TTCP）填料和晶须的复合材料，以承受应力，并“聪明”地增加钙（Ca）和磷酸盐（PO 4）离子在致龋pH下的释放。TTCP被球磨以获得四种不同的颗粒尺寸：16.2 μm，2.4 μm，1.3 μm和0.97 μm。晶须与纳米二氧化硅熔融结合TTCP作为填料在树脂中。填料水平质量分数从0%到75%变化。在pH 7.4、6和4下测量Ca和PO 4离子释放与时间的关系。复合材料的机械性能进行了测量，通过三点弯曲之前和之后，在三个pH值的溶液中浸泡。TTCP复合材料没有晶须的弯曲强度类似的树脂改性的玻璃离子（Vitremer）和以前的钙-磷酸复合材料。有晶须的TTCP复合材料的弯曲强度（平均值±标准差; n = 5）为（116 ± 9）MPa，与应力承受、非释放混杂复合材料（TPH）的（112 ± 14）MPa相似（p > 0.1）。pH 4时钙释放量为（1.22 ± 0.16）mmol/L，高于pH 6时的（0.54 ± 0.09）mmol/L和pH 7.4时的（0.22 ± 0.06）mmol/L（p < 0.05）。PO 4释放也显着增加，在酸性pH值。浸泡后，TTCP晶须复合材料匹配TPH的强度在所有三个pH值（p > 0.1）; TTCP晶须复合材料和TPH的强度约3倍的释放控制。新的TTCP-晶须复合物是“智能”的，当pH从中性降低到致龋pH 4时，当这些离子最需要抑制龋齿时，显著增加了Ca和PO 4的释放。其强度比已知的Ca-PO_4复合材料和树脂改性玻璃离子高2-3倍。这种复合材料可能具有提供必要的承重和防龋能力的组合的潜力。
Secondary caries and restoration fracture are the two main challenges facing tooth cavity restorations. The objective of this study was to develop a composite using tetracalcium phosphate (TTCP) fillers and whiskers to be stress-bearing, and to be “smart” to increase the calcium (Ca) and phosphate (PO4) ion release at cariogenic pH. TTCP was ball-milled to obtain four different particle sizes: 16.2 μm, 2.4 μm, 1.3 μm, and 0.97 μm. Whiskers fused with nano-sized silica were combined with TTCP as fillers in a resin. Filler level mass fractions varied from 0% to 75%. Ca and PO4 ion release were measured vs. time at pH of 7.4, 6, and 4. Composite mechanical properties were measured via three-point flexure before and after immersion in solutions at the three pH. TTCP composite without whiskers had flexural strength similar to a resin-modified glass ionomer (Vitremer) and previous Ca-PO4 composites. With whiskers, the TTCP composite had a flexural strength (mean ± sd; n = 5) of (116 ± 9) MPa, similar to (112 ± 14) MPa of a stress-bearing, non-releasing hybrid composite (TPH) (p > 0.1). The Ca release was (1.22 ± 0.16) mmol/L at pH of 4, higher than (0.54 ± 0.09) at pH of 6, and (0.22 ± 0.06) at pH of 7.4 (p < 0.05). PO4 release was also dramatically increased at acidic pH. After immersion, the TTCP-whisker composite matched the strength of TPH at all three pH (p > 0.1); both TTCP-whisker composite and TPH had strengths about 3-fold that of a releasing control. The new TTCP-whisker composite was “smart” and increased the Ca and PO4 release dramatically when the pH was reduced from neutral to a cariogenic pH of 4, when these ions are most needed to inhibit caries. Its strength was 2–3 fold higher than previously-known Ca-PO4 composites and resin-modified glass ionomer. This composite may have the potential to provide the necessary combination of load-bearing and caries-inhibiting capabilities.
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影响因子：
5
作者：
Lim, BS;Ferracane, JL;Condon, JR
通讯作者：
Condon, JR
影响因子：
5
作者：
Drummond, JL;Bapna, MS
通讯作者：
Bapna, MS
DOI：
10.1002/jbm.820280205
发表时间：
1994-02-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
GOLDBERG, AJ;BURSTONE, CJ;JANCAR, J
通讯作者：
JANCAR, J
影响因子：
4.2
作者：
VOGEL, GL;CHOW, LC;BROWN, WE
通讯作者：
BROWN, WE
影响因子：
5
作者：
Sarrett, DC
通讯作者：
Sarrett, DC