KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.
KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.
复制标题
KIF2A 过表达及其与胃癌患者临床病理特征和不良预后的关系
DOI：
10.1155/2016/7484516
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Zhang S;Huang F;Wang Y;Song Q;Yang X;Wu H
驱动蛋白家族蛋白2A（Kinesin family protein 2A，KIF2A）是一种M型非运动微管解聚酶，因其在多种肿瘤的发生、发展过程中的作用而受到广泛关注。在这项研究中，我们的目的是评估KIF2A的表达及其预测胃癌（GC）患者临床结局的稳健性和潜力。采用实时定量聚合酶链反应检测24对癌组织和癌旁组织中KIF2A mRNA的表达。KIF2A的免疫组织化学进行了组织芯片组成的461 GC和65匹配的相邻的非肿瘤组织手术切除，18慢性胃炎，15肠上皮化生，37低级别和62高级别上皮内瘤变获得通过胃镜活检。采用单变量和多变量考克斯回归模型进行生存分析。KIF2A高表达与组织学类型、TNM分期、淋巴结转移有关。KIF2A表达与胃癌患者5年生存率呈负相关。多因素分析提示KIF2A是胃癌的独立预后因素。本研究表明KIF2A的高表达可能作为胃癌患者预后不良的一个独立标志。
Kinesin family protein 2A (KIF2A), an M-type nonmotile microtubule depolymerase, has attracted attention for its role in carcinogenesis and poor prognoses in various human cancers. In this study, we aimed to evaluate the expression of KIF2A and its robustness and potential to predict clinical outcomes in gastric cancer (GC) patients. The messenger RNA (mRNA) expression of KIF2A was determined in 24 pairs of cancerous and adjacent nontumor tissues by real-time polymerase chain reaction. Immunohistochemistry of KIF2A was performed on a tissue microarray composed of 461 GC and 65 matched adjacent nontumor tissues removed during surgeries and 18 chronic gastritis, 15 intestinal metaplasia, and 37 low-grade and 62 high-grade intraepithelial neoplasias acquired through gastric endoscopic biopsies. Univariate and multivariate Cox regression models were used to perform survival analyses. The high KIF2A expression was significantly correlated to histological type, TNM stage, and lymph node metastasis. A negative correlation was found between KIF2A expression and the 5-year survival rate of GC patients. In addition, multivariate analysis indicated that KIF2A is an independent prognostic factor in GC. This study demonstrated the high KIF2A expression might serve as an independent marker for poor prognoses in GC patients.
登录
查看更多内容
影响因子：
3.8
作者：
Wang J;Ma S;Ma R;Qu X;Liu W;Lv C;Zhao S;Gong Y
通讯作者：
Gong Y
DOI：
10.1083/jcb.201412075
发表时间：
2015-08-31
期刊：
The Journal of cell biology
影响因子：
--
作者：
Watanabe T;Kakeno M;Matsui T;Sugiyama I;Arimura N;Matsuzawa K;Shirahige A;Ishidate F;Nishioka T;Taya S;Hoshino M;Kaibuchi K
通讯作者：
Kaibuchi K
影响因子：
3.7
作者：
Schimizzi GV;Currie JD;Rogers SL
通讯作者：
Rogers SL
影响因子：
5.6
作者：
Marra, Emanuele;Palombo, Fabio;Aurisicchio, Luigi
通讯作者：
Aurisicchio, Luigi
沉默 Kif2a 通过抑制 PI3K/Akt 信号通路诱导口腔舌鳞状细胞癌凋亡
影响因子：
3.4
作者：
Wang, Ketao;Lin, Changlong;Wei, Fengcai
通讯作者：
Wei, Fengcai