CED: a conformational epitope database.
CED: a conformational epitope database.
复制标题
CED：构象表位数据库
DOI：
10.1186/1471-2172-7-7
复制
发表时间：
2006-04-07
期刊：
影响因子：
3
通讯作者：
Honda, Wataru
中科院分区：
文献类型：
--
作者：
Huang, Jian;Honda, Wataru
抗原表位为疾病的预防、诊断和治疗提供了有价值的信息。最近，越来越多的数据库集中在不同类型的表位已经成为可用。构象表位是由连续不连续但在三维空间中紧密相连的残基形成的重要形式的表位。这些表位具有隐含的结构信息，使其对理论和应用生物医学研究都具有吸引力。然而，大多数现有的数据库集中在线性，而不是构象epitopes.DescriptionWe描述CED，一个特殊的数据库定义良好的构象表位。CED提供了构象表位的集合和相关信息，包括表位的残基组成和位置、表位的免疫学性质、表位的来源抗原和相应的抗体。该数据库中的所有条目都是从同行评审期刊上发表的文章中手动整理的。该数据库可通过用户友好的网络界面进行浏览或搜索。CED中的大多数表位也可以在其3D结构的背景下交互式地查看。此外，条目也超链接到各种数据库，如Swiss-Prot，PDB，KEGG和PubMed，提供广泛的背景informations.ConclusionA构象表位数据库，称为CED已被开发为一个信息资源，为研究人员参与理论和应用免疫学研究。它补充了其他现有的专门表位数据库。该数据库可在 http://web.kuicr.kyoto-u.ac.jp/~ced
BackgroundAntigen epitopes provide valuable information useful for disease prevention, diagnosis, and treatment. Recently, more and more databases focusing on different types of epitopes have become available. Conformational epitopes are an important form of epitope formed by residues that are sequentially discontinuous but close together in three-dimensional space. These epitopes have implicit structural information, making them attractive for both theoretical and applied biomedical research. However, most existing databases focus on linear rather than conformational epitopes.DescriptionWe describe CED, a special database of well defined conformational epitopes. CED provides a collection of conformational epitopes and related information including the residue make up and location of the epitope, the immunological property of the epitope, the source antigen and corresponding antibody of the epitope. All entries in this database are manually curated from articles published in peer review journals. The database can be browsed or searched through a user-friendly web interface. Most epitopes in CED can also be viewed interactively in the context of their 3D structures. In addition, the entries are also hyperlinked to various databases such as Swiss-Prot, PDB, KEGG and PubMed, providing wide background information.ConclusionA conformational epitope database called CED has been developed as an information resource for investigators involved in both theoretical and applied immunology research. It complements other existing specialised epitope databases. The database is freely available at http://web.kuicr.kyoto-u.ac.jp/~ced
登录
查看更多内容
影响因子：
64.8
作者：
Cho, HS;Mason, K;Leahy, DJ
通讯作者：
Leahy, DJ
影响因子：
56.9
作者：
STEIMER, KS;SCANDELLA, CJ;HAIGWOOD, NL
通讯作者：
HAIGWOOD, NL
影响因子：
64.8
作者：
Nybakken GE;Oliphant T;Johnson S;Burke S;Diamond MS;Fremont DH
通讯作者：
Fremont DH
影响因子：
64.8
作者：
BARLOW, DJ;EDWARDS, MS;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
13.6
作者：
Mackay, IR;Rowley, MJ
通讯作者：
Rowley, MJ