Lichen sclerosus is frequently present in penile squamous cell carcinomas but is not always associated with oncogenic human papillomavirus.
Lichen sclerosus is frequently present in penile squamous cell carcinomas but is not always associated with oncogenic human papillomavirus.
复制标题
硬化性地衣经常出现在阴茎鳞状细胞癌中，但并不总是与致癌性人乳头瘤病毒相关。
DOI：
10.1046/j.1365-2133.2003.05326.x
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
P. Bernard
中科院分区：
文献类型：
--
作者：
G. Perceau;C. Derancourt;Christine Clavel;A. Durlach;Michel Pluot;B. Lardennois;P. Bernard
背景
阴茎鳞状细胞癌 (SCC) 可能发生在先前存在的硬化性苔藓 (LS) 病变上。然而，阴茎 SCC 中 LS 组织学变化的发生率尚未明确。此外，有时在阴茎鳞状细胞癌中检测到粘膜致癌性人乳头瘤病毒（HPV），但尚未在 LS 相关阴茎鳞状细胞癌中系统地寻找。
目标
旨在确定一系列阴茎 SCC 患者中 LS 组织学变化和粘膜致癌 HPV 的患病率。
方法
对 14 年来来自同一所大学医院的连续经组织学证实的阴茎 SCC 病例进行回顾性选择和审查。系统地寻找 LS 的组织学迹象。使用通用引物 GP5+/GP6+（允许检测粘膜 HPV）和致癌类型 16-、18-、31- 和 33 特异性引物，通过聚合酶链反应 (PCR) 扩增石蜡包埋的皮肤样本中的 DNA 来检测 HPV。
结果
发现18例阴茎鳞状细胞癌。患者诊断时的平均 +/- SD 年龄为 67.3 岁（14.5 岁）。在 18 例病例中，有 8 例 (44%) 的 SCC 与 LS 的组织学特征相关。对 17 份 SCC 皮肤活检标本（9 份无 LS 组织学标本，8 份有 LS 组织学标本）进行 HPV PCR 扩增。其中 6 例 (35%) 检测到粘膜 HPV。不具有 LS 组织学特征的 9 个 SCC 中有 5 个呈粘膜 HPV 阳性：3 个具有 HPV 16 型，2 个仅具有通用引物。相比之下，与 LS 相关的所有 8 个 SCC 的致癌 HPV 类型均为阴性，尽管其中一个 SCC 的通用引物呈阳性。
结论
阴茎 SCC 似乎经常与 LS 组织学变化相关。与外阴 SCC 一样，我们发现非 LS 相关的阴茎 SCC 往往经常与致癌 HPV 感染相关，而 LS 相关的阴茎 SCC 则不然。需要更大的系列来证实这种关联。
BACKGROUND
Penile squamous cell carcinoma (SCC) may occur on pre-existing lesions of lichen sclerosus (LS). However, the prevalence of histological changes of LS in penile SCC is not well established. Moreover, mucosal oncogenic human papillomaviruses (HPVs) are sometimes detected in penile SCC, but have not been systematically sought in LS-associated penile SCC.
OBJECTIVES
To establish the prevalence of LS histological changes and of mucosal oncogenic HPV in a series of patients with penile SCC.
METHODS
Consecutive cases of histologically proven penile SCC from a single university hospital over a 14-year period were retrospectively selected and reviewed. Histological signs of LS were systematically sought. HPV was detected by polymerase chain reaction (PCR) amplification of DNA from paraffin-embedded skin samples using general primers GP5+/GP6+ (allowing detection of mucosal HPV) and oncogenic type 16-, 18-, 31- and 33-specific primers.
RESULTS
Eighteen cases of penile SCC were found. The mean +/- SD age of patients at diagnosis was 67.3 (14.5 years). In eight of 18 (44%) cases, SCC was associated with histological features of LS. Seventeen skin biopsy specimens of SCC (nine without and eight with LS histology) were subjected to PCR amplification for HPV. Mucosal HPV was detected in six of them (35%). Five of nine SCCs without histological features of LS were positive for mucosal HPV: three with HPV type 16 and two with only general primers. In contrast, all eight SCCs associated with LS were negative for oncogenic HPV types, although one was positive with general primers.
CONCLUSIONS
Penile SCC seems to be frequently associated with LS histological changes. As with vulval SCC, we found that non-LS-associated penile SCC tended to be frequently associated with oncogenic HPV infection, whereas LS-associated penile SCC was not. Larger series are needed to confirm this association.
人乳头瘤病毒对人类细胞的永生化和转化。
影响因子：
--
作者：
McDougall,JK
通讯作者：
McDougall,JK