Mobile phone based clinical microscopy for global health applications.
Mobile phone based clinical microscopy for global health applications.
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基于手机的临床显微镜用于全球健康应用。
DOI：
10.1371/journal.pone.0006320
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发表时间：
2009-07-22
期刊：
影响因子：
3.7
通讯作者：
Fletcher, Daniel A.
中科院分区：
文献类型：
--
作者：
Breslauer, David N.;Maamari, Robi N.;Switz, Neil A.;Lam, Wilbur A.;Fletcher, Daniel A.
光学显微镜检查为血液病和传染病的诊断和筛查提供了一种简单、经济有效和重要的方法。然而，在世界许多地区，所需的设备要么没有，要么不够便携，操作人员可能没有充分的培训来充分利用所获得的图像。与直觉相反的是，这些地区通常都有移动的电话网络提供良好的服务，这表明有可能利用便携式、支持摄像头的移动的电话进行诊断成像和远程医疗。为此，我们已经建立了一个移动的手机安装光学显微镜，并证明其潜在的临床应用成像恶性疟原虫感染和镰状红细胞在明场和M。结核病感染的痰液样本在荧光与LED激发。在所有情况下，分辨率都超过了检测血细胞和微生物形态所需的分辨率，对于结核病样本，我们进一步利用数字化图像，通过图像分析软件演示了自动化芽孢杆菌计数。我们希望这样一个远程医疗系统，通过移动的电话全球医疗保健-提供廉价的明场和荧光显微镜与自动图像分析集成-提供一个重要的工具，疾病诊断和筛查，特别是在发展中国家和农村地区的实验室设施是稀缺的，但移动的电话基础设施是广泛的。
Light microscopy provides a simple, cost-effective, and vital method for the diagnosis and screening of hematologic and infectious diseases. In many regions of the world, however, the required equipment is either unavailable or insufficiently portable, and operators may not possess adequate training to make full use of the images obtained. Counterintuitively, these same regions are often well served by mobile phone networks, suggesting the possibility of leveraging portable, camera-enabled mobile phones for diagnostic imaging and telemedicine. Toward this end we have built a mobile phone-mounted light microscope and demonstrated its potential for clinical use by imaging P. falciparum-infected and sickle red blood cells in brightfield and M. tuberculosis-infected sputum samples in fluorescence with LED excitation. In all cases resolution exceeded that necessary to detect blood cell and microorganism morphology, and with the tuberculosis samples we took further advantage of the digitized images to demonstrate automated bacillus counting via image analysis software. We expect such a telemedicine system for global healthcare via mobile phone – offering inexpensive brightfield and fluorescence microscopy integrated with automated image analysis – to provide an important tool for disease diagnosis and screening, particularly in the developing world and rural areas where laboratory facilities are scarce but mobile phone infrastructure is extensive.
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影响因子：
9.4
作者：
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通讯作者：
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DOI：
10.1016/j.trstmh.2008.10.015
发表时间：
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影响因子：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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