Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer
Adenylyl cyclase-associated protein 1-targeted nanoparticles as a novel strategy for the treatment of metastatic non-small cell lung cancer
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腺苷酸环化酶相关蛋白1靶向纳米颗粒作为治疗转移性非小细胞肺癌的新策略
DOI：
10.3892/ijo.2019.4822
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发表时间：
2019-06
影响因子：
5.2
通讯作者：
Wang Changhui
中科院分区：
文献类型：
--
作者：
Liu Yang;Xie Shuanshuan;Zeng Jie;Song Xiaolian;Tan Min;He Dannong;Wang Jie;Wang Ping;Zhu Jun;Wang Changhui
非小细胞肺癌（NSCLC）是世界上最致命的癌症之一。腺苷酸环化酶相关蛋白1（CAP 1）属于参与癌性肿瘤发展的环化酶相关蛋白家族。我们小组先前的一项研究证实了CAP 1、肺癌和癌细胞转移之间的关联。在本研究中，聚（乳酸-聚乙醇酸; PLGA）/CAP 1-小干扰（si）RNA纳米粒的制备和交付到A549细胞。基于迁移实验和动物实验的结果，测量PLGA/siCAP 1-siRNA纳米粒用于siRNA递送的性能。多功能纳米颗粒被确定为能够抑制CAP 1表达，这减少了体外和体内NSCLC转移。因此，本研究的结果突出了PLGA/siCAP 1-siRNA纳米颗粒用于治疗NSCLC转移的潜在用途。
Non-small cell lung cancer (NSCLC) is one of the most fatal cancers worldwide. Adenylyl cyclase-associated protein 1 (CAP1) belongs to a family of cyclase-associated proteins that are involved in the development of cancerous tumors. A previous study by our group confirmed the association between CAP1, lung cancer and the metastasis of cancer cells. In the present study, poly(lactic-polyglycolic acid; PLGA)/CAP1-small interfering (si)RNA nanoparticles were prepared and delivered into A549 cells. The performance of PLGA/siCAP1-siRNA nanoparticles for siRNA delivery was measured based on the results of migration assay and animal experiments. The multifunctional nanoparticles were determined to be capable of inhibiting CAP1 expression, which reduced NSCLC metastasis in vitro and in vivo. Therefore, the findings of the current study highlighted the potential use of PLGA/siCAP1-siRNA nanoparticles for the treatment of NSCLC metastasis.
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影响因子：
5
作者：
Yamazaki, Ken;Takamura, Masaaki;Sakamoto, Michiie
通讯作者：
Sakamoto, Michiie
CAP1在人类上皮卵巢癌中过表达，并促进细胞增殖。
影响因子：
5.4
作者：
Hua M;Yan S;Deng Y;Xi Q;Liu R;Yang S;Liu J;Tang C;Wang Y;Zhong J
通讯作者：
Zhong J
影响因子：
28.2
作者：
Tabernero, Josep;Shapiro, Geoffrey I.;Burris, Howard A., III
通讯作者：
Burris, Howard A., III
影响因子：
3.5
作者：
Aisner, Dara L.;Marshall, Carrie B.
通讯作者：
Marshall, Carrie B.
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.