Comfort food is comforting to those most stressed: evidence of the chronic stress response network in high stress women.
Comfort food is comforting to those most stressed: evidence of the chronic stress response network in high stress women.
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DOI：
10.1016/j.psyneuen.2011.04.005
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发表时间：
2011-11
影响因子：
3.7
通讯作者：
Epel, Elissa S.
中科院分区：
文献类型：
--
作者：
Tomiyama, A. Janet;Dallman, Mary F.;Epel, Elissa S.
长期紧张的啮齿类动物被允许吃高热量的“舒适”食物，会产生更多的肠系膜脂肪，这反过来又会抑制下丘脑-垂体-肾上腺皮质（HPA）轴的活动。我们测试了人类中是否存在类似的关系，至少在横截面上。59名健康的绝经前妇女暴露于一个标准的实验室应激源，以检查HPA对急性应激的反应，并进行了基础皮质醇和地塞米松给药的反应昼夜唾液采样。根据感知的压力分数，女性被分为低压力和高压力的极端四分位数。我们发现，作为假设，高压力组有显着更大的BMI和矢状径，并报告更多的压力事件后进食。在对急性实验室应激源的反应中，高应激组表现出迟钝的皮质醇反应，较低的昼夜皮质醇水平，以及对地塞米松的更大抑制。这些横断面研究结果支持了动物模型，该模型表明，面对高热量的长期适应慢性压力会导致内脏脂肪积累更多（通过摄入高热量食物），这反过来又会调节HPA轴反应，导致皮质醇水平降低。
Chronically stressed rodents who are allowed to eat calorie-dense “comfort” food develop greater mesenteric fat, which in turn dampens hypothalamic-pituitary-adrenocortical (HPA) axis activity. We tested whether similar relations exist in humans, at least cross-sectionally. Fifty-nine healthy premenopausal women were exposed to a standard laboratory stressor to examine HPA response to acute stress and underwent diurnal saliva sampling for basal cortisol and response to dexamethasone administration. Based on perceived stress scores, women were divided into extreme quartiles of low vs. high stress categories. We found as hypothesized that the high stress group had significantly greater BMI and sagittal diameter, and reported greater eating after stressful events. In response to acute lab stressor, the high stress group showed a blunted cortisol response, lower diurnal cortisol levels, and greater suppression in response to dexamethasone. These cross-sectional findings support the animal model, which suggests that long-term adaptation to chronic stress in the face of dense calories result in greater visceral fat accumulation (via ingestion of calorie-dense food), which in turn modulates HPA axis response, resulting in lower cortisol levels.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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