The possible role of vascular endothelial growth factor (VEGF) in gastric ulcer healing: effect of sofalcone on VEGF release in vitro.
The possible role of vascular endothelial growth factor (VEGF) in gastric ulcer healing: effect of sofalcone on VEGF release in vitro.
复制标题
血管内皮生长因子（VEGF）在胃溃疡愈合中的可能作用：索法酮对体外 VEGF 释放的影响。
DOI：
10.1097/00004836-199800001-00029
复制
发表时间：
1998
影响因子：
2.9
通讯作者：
M. Omata
中科院分区：
文献类型：
--
作者：
M. Takahashi;S. Maeda;K. Ogura;A. Terano;M. Omata
血管生成在胃溃疡的修复中起重要作用。几种生长因子参与血管生成，其中，血管内皮生长因子（VEGF）受到了相当大的关注，因为它是唯一特异性作用于内皮细胞的因子，并且与其他血管生成生长因子不同，它具有根据经典分泌途径进行细胞外转运所需的疏水信号肽。我们最近证实了VEGF在胃溃疡修复中的作用。以往的研究证实，索法酮对胃溃疡的愈合具有显著的促进作用，其机制可能是通过促进胃细胞前列腺素（PG）的释放而实现的。我们的数据表明，PG刺激胃成纤维细胞VEGF的表达。在本报告中，我们假设索法酮的临床作用是由VEGF表达介导的，我们证明索法酮刺激原代培养的胃成纤维细胞释放VEGF。
Angiogenesis plays an important role in gastric ulcer repair. Several growth factors are involved in angiogenesis and, of these, vascular endothelial growth factor (VEGF) has received considerable attention because it is the only factor that acts specifically on endothelial cells and, unlike other angiogenic growth factors, has the hydrophobic signal peptide required for extracellular transport according to classical secretory pathways. We have lately demonstrated the role of VEGF in gastric ulcer repair. Previous reports confirmed that sofalcone has remarkable effects on gastric ulcer healing, which may be mediated by its stimulatory effect on prostaglandin (PG) release in gastric cells. Our data indicate that PGs stimulate VEGF expression in gastric fibroblasts. In this report we hypothesize that the clinical effect of sofalcone is mediated by VEGF expression and we demonstrate that sofalcone stimulates VEGF release by gastric fibroblasts in primary culture.
影响因子：
56.9
作者：
DEVRIES, C;ESCOBEDO, JA;WILLIAMS, LT
通讯作者：
WILLIAMS, LT
迟发型过敏性皮肤反应中血管通透性因子（VPF/VEGF）及其内皮细胞受体的过度表达。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brown,LF;Olbricht,SM;Berse,B;Jackman,RW;Matsueda,G;Tognazzi,KA;Manseau,EJ;Dvorak,HF;VandeWater,L
通讯作者：
VandeWater,L
影响因子：
29.4
作者：
Takahashi, T;Nakamura, K;Owyang, C
通讯作者：
Owyang, C