YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer.
YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer.
复制标题
雅普在人类癌症生物力学和耐药性的十字路口。
DOI：
10.3390/ijms241512491
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发表时间：
2023-08-06
影响因子：
5.6
通讯作者：
Tang, Xin
中科院分区：
文献类型：
--
作者：
Huang, Miao;Wang, Heyang;Mackey, Cole;Chung, Michael C. C.;Guan, Juan;Zheng, Guangrong;Roy, Arkaprava;Xie, Mingyi;Vulpe, Christopher;Tang, Xin
关键词：
生物力学力在生物学、疾病和医学中具有根本的重要性。机械生物学是一个新兴的跨学科领域，研究生物机制如何受到生物力学力量的调节，以及如何利用物理原理来创新新的治疗策略。本文综述了机械生物学中一种重要的机械敏感蛋白--yes相关蛋白（雅普）及其在肿瘤耐药中的作用。具体而言，本文讨论了三个主题：雅普是如何在活细胞中机械调节;分子机械生物学机制，其中雅普，沿着其他功能途径，影响癌细胞（特别是肺癌细胞）的耐药性;最后，如何机械调节雅普可以影响耐药性，反之亦然。通过整合这些主题，我们提出了一个统一的框架，该框架有可能为新型机械医学的设计带来理论见解，并推进下一代癌症疗法以抑制肿瘤进展和转移。
Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specifically, the article discusses three topics: how YAP is mechanically regulated in living cells; the molecular mechanobiology mechanisms by which YAP, along with other functional pathways, influences drug resistance of cancer cells (particularly lung cancer cells); and finally, how the mechanical regulation of YAP can influence drug resistance and vice versa. By integrating these topics, we present a unified framework that has the potential to bring theoretical insights into the design of novel mechanomedicines and advance next-generation cancer therapies to suppress tumor progression and metastasis.
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DOI：
10.1126/science.1171643
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Discher DE;Mooney DJ;Zandstra PW
通讯作者：
Zandstra PW
影响因子：
50.3
作者：
Girotti MR;Lopes F;Preece N;Niculescu-Duvaz D;Zambon A;Davies L;Whittaker S;Saturno G;Viros A;Pedersen M;Suijkerbuijk BM;Menard D;McLeary R;Johnson L;Fish L;Ejiama S;Sanchez-Laorden B;Hohloch J;Carragher N;Macleod K;Ashton G;Marusiak AA;Fusi A;Brognard J;Frame M;Lorigan P;Marais R;Springer C
通讯作者：
Springer C
影响因子：
16.6
作者：
Cui, Yidan;Hameed, Feroz M.;Yang, Bo;Lee, Kyunghee;Pan, Catherine Qiurong;Park, Sungsu;Sheetz, Michael
通讯作者：
Sheetz, Michael
影响因子：
21.3
作者：
Balaban, NQ;Schwarz, US;Geiger, B
通讯作者：
Geiger, B
超分辨率成像揭示 F-肌动蛋白和 GPCR 对 YAP 的机械力调节
影响因子：
6.7
作者：
Gao, Jing;He, Lingli;Wang, Hongda
通讯作者：
Wang, Hongda