Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease.
Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease.
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DOI：
10.1186/s12967-018-1635-z
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发表时间：
2018-09-26
影响因子：
7.4
通讯作者：
Zeng Y
中科院分区：
文献类型：
--
作者：
Yan F;Gao H;Zhao H;Bhatia M;Zeng Y
气道平滑肌（ASM）在气道结构和功能中起着不可缺少的作用。ASM功能障碍在慢性阻塞性肺疾病（COPD）的发病机制中起着核心作用，并有助于气道收缩性、炎症反应、免疫反应、表型、数量和大小的改变。ASM通过多种机制在COPD中发挥关键作用，包括[Ca2+]i诱导的收缩性和舒张性改变、细胞增殖和肥大、细胞外细胞因子的产生和调节以及促炎和抗炎介质的释放。ASM的多重功能障碍有助于调节气道对刺激、重塑和纤维化的反应，并影响肺的顺应性。本文综述了多种因素在COPD中ASM功能障碍发展中的调控作用，旨在了解ASM功能障碍启动的调控机制，探讨ASM在COPD气道结构和功能改变及COPD新治疗策略开发中的临床意义。
The airway smooth muscle (ASM) plays an indispensable role in airway structure and function. Dysfunction in ASM plays a central role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and contributes to alterations of contractility, inflammatory response, immunoreaction, phenotype, quantity, and size of airways. ASM makes a key contribution in COPD by various mechanisms including altered contractility and relaxation induce by [Ca2+]i, cell proliferation and hypertrophy, production and modulation of extracellular cytokines, and release of pro-and-anti-inflammatory mediators. Multiple dysfunctions of ASM contribute to modulating airway responses to stimuli, remodeling, and fibrosis, as well as influence the compliance of lungs. The present review highlights regulatory roles of multiple factors in the development of ASM dysfunction in COPD, aims to understand the regulatory mechanism by which ASM dysfunctions are initiated, and explores the clinical significance of ASM on alterations of airway structure and function in COPD and development of novel therapeutic strategies for COPD.
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