What is the role for donor natural killer cells after nonmyeloablative conditioning?
What is the role for donor natural killer cells after nonmyeloablative conditioning?
复制标题
在非甲状腺素调节后，供体天然杀手细胞的作用是什么？
DOI：
10.1016/j.bbmt.2009.01.018
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Storb R
中科院分区：
文献类型：
--
作者：
Baron F;Petersdorf EW;Gooley T;Sandmaier BM;Malkki M;Chauncey TR;Maloney DG;Storb R
我们研究了早期（第14、28和42天）供体T细胞和自然杀伤（NK）细胞植入的克里思、受体杀伤细胞免疫球蛋白样受体（KIR）配体缺失以及供体抑制和激活KIR基因的数量对282例接受非清髓性预处理的恶性血液病患者造血细胞移植（HCT）结果的影响。将嵌合体水平建模为连续线性变量，我们发现高早期供体T细胞嵌合体与急性GVHD显著相关（p=0.01），而高供体NK细胞水平没有这种相关性（p=0.38）。相反，高供体NK细胞水平与低复发风险显著相关（p=0.0009），而与高供体T细胞嵌合体无显著相关性（p=0.10）。供体T细胞和NK细胞嵌合水平与GVHD和复发之间的定性关联在调整受体KIR配体或供体抑制或激活KIR基因的数量后没有改变。总之，供体NK细胞的迅速植入与复发风险降低相关，但与GVHD无关，而T细胞则匡威。
We investigated the impacts of tempo of early (days 14, 28, and 42) donor T-cell and natural killer (NK) cell engraftment, missing recipient killer cell immunoglobulin-like receptor (KIR) ligands, and numbers of donor inhibitory and activating KIR genes on hematopoietic cell transplantation (HCT) outcomes in 282 patients with hematological malignancies given nonmyeloablative conditioning. Modeling chimerism levels as continuous linear variable, we found that high early donor T-cell chimerism was significantly associated with acute GVHD (p=0.01), while high donor NK cell levels had no such association (p=0.38). Conversely, high donor NK cells levels were significantly associated with low relapse risk (p=0.0009), while no significant association was seen with high donor T-cell chimerism (p=0.10). The qualitative associations between donor T-cell and NK cell chimerism levels and GVHD and relapse did not change after adjustment for the presence of recipient KIR ligands or numbers of donor inhibitory or activating KIR genes. In conclusion, prompt engraftment of donor NK cells correlated with lessened risks of relapse but not with GVHD, while the converse was true for T-cells.
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