Improvement of Ulcerative Colitis by Aspartate via RIPK Pathway Modulation and Gut Microbiota Composition in Mice.
Improvement of Ulcerative Colitis by Aspartate via RIPK Pathway Modulation and Gut Microbiota Composition in Mice.
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天冬氨酸通过 RIPK 通路调节和小鼠肠道微生物群组成改善溃疡性结肠炎
DOI：
10.3390/nu14183707
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发表时间：
2022-09-08
期刊：
影响因子：
5.9
通讯作者：
He, Liuqin
中科院分区：
文献类型：
--
作者：
Hu, Xian;He, Xinmiao;Peng, Can;He, Yiwen;Wang, Chenyu;Tang, Wenjie;Chen, Heshu;Feng, Yanzhong;Liu, Di;Li, Tiejun;He, Liuqin
The intestine requires a great deal of energy to maintain its health and function; thus, energy deficits in the intestinal mucosa may lead to intestinal damage. Aspartate (Asp) is an essential energy source in the intestinal mucosa and plays a vital part in gut health. In the current study, we hypothesized that dietary supplementation of Asp could alleviate DSS-induced colitis via improvement in the colonic morphology, oxidative stress, cell apoptosis, and microbiota composition in a mouse model of dextran. Asp administration decreased the disease activity index, apoptosis, myeloperoxidase, eosinophil peroxidase, and proinflammatory cytokine (IL-1β and TNF-α) concentrations in the colonic tissue, but improved the body weight, average daily food intake, colonic morphology, and antioxidant-related gene (GPX1 and GPX4) expression in DSS-treated mice. Expression levels of RIPK1 and RIPK3 were increased in the colon following Asp administration in the DSS-induced mice, whereas the MLKL protein expression was decreased. 16S rRNA sequencing showed that Asp treatment increased the abundance of Lactobacillus and Alistipes at the gene level, and Bacteroidetes at the phylum level, but decreased the abundance of Actinobacteria and Verrucomicrobia at the phylum level. Asp may positively regulate the recovery of DSS-induced damage by improving the immunity and antioxidative capacity, regulating RIPK signaling and modulating the gut microbiota composition.
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影响因子：
8.8
作者：
Wang, Biao;Liu, Yang;Zhou, Xiao-Qiu
通讯作者：
Zhou, Xiao-Qiu
影响因子：
12.4
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Kearney, C. J.;Cullen, S. P.;Martin, S. J.
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Pasparakis M
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Shyamaladevi, Chennam Srinivasulu
影响因子：
9.3
作者：
Wu, Minna;Li, Puze;Zhong, Genshen
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Zhong, Genshen