Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.
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DOI:
10.3390/polym3031377
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发表时间:
2011-09-01
期刊:
影响因子:
5
通讯作者:
Siegel SJ
Siegel SJ
中科院分区:
工程技术3区
文献类型:
--
作者:
Makadia HK;Siegel SJ

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在过去的二十年中,聚乳酸-共-乙醇酸(PLGA)一直是最有吸引力的聚合物候选人之一,用于制造药物输送和组织工程应用的装置。PLGA具有生物相容性和生物可降解性,具有广泛的侵蚀时间,具有可调的机械性能,最重要的是,是FDA批准的聚合物。特别地,PLGA已经被广泛研究用于开发用于商业用途和研究中的小分子药物、蛋白质和其它大分子的受控递送的装置。这份手稿描述了这些装置的各种制造技术以及影响其降解和药物释放的因素。
In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.
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