A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction--the China Rural Health Initiative Sodium Reduction Study.
A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction--the China Rural Health Initiative Sodium Reduction Study.
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DOI：
10.1016/j.ahj.2013.07.009
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发表时间：
2013-11
影响因子：
4.8
通讯作者：
Neal, Bruce
中科院分区：
文献类型：
--
作者：
Li, Nicole;Yan, Lijing L.;Niu, Wenyi;Labarthe, Darwin;Feng, Xiangxian;Shi, Jingpu;Zhang, Jianxin;Zhang, Ruijuan;Zhang, Yuhong;Chu, Hongling;Neiman, Andrea;Engelgau, Michael;Elliott, Paul;Wu, Yangfeng;Neal, Bruce
心血管疾病是中国死亡和残疾的主要原因。由过量摄入膳食钠引起的高血压很普遍，有效的减钠计划有可能改善心血管健康。本研究是一项在中国北方五省进行的大规模随机分组试验。从每个省选出两个县，每个县选出12个乡镇，共120个集群。在每个乡镇内，选择一个村庄参加，按县分层，按1：1随机分配。减少钠的干预措施包括社区卫生教育和以提供盐替代品为基础的食品供应战略。随机选择30个干预村进行食盐替代品价格补贴。控制村庄继续通常的做法。研究的主要结果是根据24小时尿液分析估计的膳食钠摄入水平。该试验于2011年4月招募并随机分配了120个乡镇。同年5月至6月，在60个干预村开始了减钠计划，计划于2012年10月至12月进行结果调查。基线数据收集显示，随机分组在各组之间实现了良好的平衡。中国农村健康倡议的建立使得这项大规模试验得以启动，旨在确定一种新颖的、可扩展的降低膳食钠和控制血压的策略。如果证明有效，这种干预措施可以在中国大部分地区和世界其他国家以低成本实施。
Cardiovascular diseases are the leading cause of death and disability in China. High blood pressure caused by excess intake of dietary sodium is widespread and an effective sodium reduction program has potential to improve cardiovascular health. This study is a large-scale, cluster-randomized, trial done in five Northern Chinese provinces. Two counties have been selected from each province and 12 townships in each county making a total of 120 clusters. Within each township one village has been selected for participation with 1:1 randomization stratified by county. The sodium reduction intervention comprises community health education and a food supply strategy based upon providing access to salt substitute. Subsidization of the price of salt substitute was done in 30 intervention villages selected at random. Control villages continued usual practices. The primary outcome for the study is dietary sodium intake level estimated from assays of 24 hour urine. The trial recruited and randomized 120 townships in April 2011. The sodium reduction program was commenced in the 60 intervention villages between May and June of that year with outcome surveys scheduled for October to December 2012. Baseline data collection shows that randomisation achieved good balance across groups. The establishment of the China Rural Health Initiative has enabled the launch of this large-scale trial designed to identify a novel, scalable strategy for reduction of dietary sodium and control of blood pressure. If proved effective, the intervention could plausibly be implemented at low cost in large parts of China and other countries worldwide.
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影响因子：
37.8
作者：
Wu, Yangfeng;Huxley, Rachel;Yang, Xiaoguang
通讯作者：
Yang, Xiaoguang
影响因子：
7.1
作者：
Chang, Hsing-Yi;Hu, Yu-Whuei;Pan, Wen-Harn
通讯作者：
Pan, Wen-Harn
制定和评估复杂的干预措施：新的医学研究委员会指南。
DOI：
10.1136/bmj.a1655
发表时间：
2008-09-29
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Craig P;Dieppe P;Macintyre S;Michie S;Nazareth I;Petticrew M;Medical Research Council Guidance
通讯作者：
Medical Research Council Guidance
影响因子：
168.9
作者：
Murray, Christopher J. L.;Vos, Theo;Lopez, Alan D.
通讯作者：
Lopez, Alan D.
影响因子：
168.9
作者：
Beaglehole, Robert;Bonita, Ruth;Watt, Judith
通讯作者：
Watt, Judith