Factors associated with corneal graft survival in the cornea donor study.
Factors associated with corneal graft survival in the cornea donor study.
复制标题
角膜供体研究中与角膜移植生存有关的因素。
DOI：
10.1001/jamaophthalmol.2014.3923
复制
发表时间：
2015-03
影响因子：
8.1
通讯作者：
Woody, Jason
中科院分区：
文献类型：
--
作者：
Sugar, Alan;Gal, Robin L.;Kollman, Craig;Raghinaru, Dan;Dontchev, Mariya;Croasdale, Christopher R.;Feder, Robert S.;Holland, Edward J.;Lass, Jonathan H.;Macy, Jonathan I.;Mannis, Mark J.;Smith, Patricia W.;Soukiasian, Sarkis H.;Beck, Roy W.;Chow, Christopher Y.;Dunn, Steven P.;Heidemann, David G.;MacLeod, Tina;Price, Theresa;Belin, Michael W.;Schultze, Robert L.;Semeiks, Cassandra;Sutherland, Charity;Oliva, Matthew S.;Rotkis, Walter M.;Huddleston, Cindy;McDonald, Richard;Taylor, Joy;Verdier, David D.;Johnson, Paula;Lass, Jonathan H.;Reinhart, William J.;Singh, Annapurna;Thomas, Joseph M.;Trocme, Stefan D.;Brown, Lauren;Mines, Kristee;Murray, Megin;Norell, Marie;Shaffer, Stephanie;Washington, Kalisha;Hamilton, Stephen M.;Jayawant, Gina C.;Lee, W. Barry;Larson, Jacqueline;Simner, Melanie;Gross, Robert H.;Shaw, Edward L.;Blackburn, Pamela;Maskin, Steven L.;Eggers, Eloise;Lutzk, Harriet;Wagner, Sherry;Ayres, Brandon D.;Nagra, Parveen K.;Raber, Irving M.;DiCicco, Joy;Spanelis-Diaz, Irene;Sugar, Joel;Tu, Elmer;Byrne, Dolores;Gorovoy, Mark S.;Glinos, Deborah;Lehet, Robert;Nolan, Bernadette;Manning, Francis J.;Shelly, Brenda;Boland, Thomas S.;Pascucci, Stephen E.;Kunz, Donna;Farjo, Qais A.;Meyer, Roger F.;Mian, Shahzad I.;Soong, H. Kaz;Sugar, Alan;Hussain, Munira;Knowlton, Jessica;Pope, Cindy;Radenbaugh, Paulina;Kellogg, W. K.;Galentine, Paul G.;Rosen, Gerald B.;Ugland, David N.;Schafer, Mara;Hannush, Sadeer B.;Bokosky, John E.;Riner, Donna;Caudill, James W.;Coleman, Lea;Feder, Robert S.;Kaminski, Lori;Affeldt, John C.;Blanton, Christopher L.;Cancino, Monica;Holland, Edward J.;Jost, Amy;Meyer, Aimee;Bowman, R. Wayne;Cavanagh, H. Dwight;El-Agha, Mohamed-Sameh H.;McCulley, James P.;Molai, Mike;Gillette, Thomas E.;Buchan, Isabel;Corrigan, Michelle;Leahey, Alan B.;Malinowski, Ann;Croasdale, Christopher R.;Blaser, Stephanie;DeBaufer, Jane;Moudry, LuAnne;Eiferman, Richard A.;Shields, Shannon;Soukiasian, Sarkis H.;Brown, Ken;Morse, Patti-Ann;Sexton, Patricia;Dholakia, Bhairavi K.;Randleman, James B.;Stulting, R. Doyle;Brown, Jayne;Larson, Paul;Loupe, Donna;Stark, Walter J.;Pratzer, Kimberly;Kenyon, Kenneth R.;Rodman, Richard C.;Crompton, Kari;Beebe, Walter E.;Gelender, Henry;Heinle, Sidney;Ching, Steven S.;Plotnik, Ronald D.;Anstey, Jennifer;Fedick, Nancy;MacDowell, Peter;Skrine, Karen;Stoutenburg, Ann;Goldberg, Marc A.;Owen, Kathy;Sumers, Karen;Spentz, Lisa;Wykle, Amanda;Chem, Kenneth C.;Fynn-Thompson, Nicoletta A.;McColgin, Ann Z.;Raizman, Michael B.;Healy, Patricia;Pereira, Jacqueline;Rosenfeld, Steven I.;Salvati, Ellen;Beach, Delray;Davis, Elizabeth A.;Hardten, David R.;Lindstrom, Richard L.;DeMarchi, Janet;Jordan, Alexander;Lindstrom, Richard;Mork, Sara;Rockvam, Allison;Mannis, Mark J.;Imson, Katrina;Saya, Michael;Sponzo, Marilyn;Wallace, Cindy;Ford, Jerry G.;Meisler, David M.;Holody, Laura;Dobbins, Kendall;Price, Francis W., Jr.;Zeh, William G.;Quillin, Clorissa;Berkowitz, Peter J.;Zubik, Lori;Lindquist, Thomas D.;Sims, Linda;Goodman, Daniel F.;Ali, Abdulfatah M.;Beatty, Richard F.;Sutphin, John E.;Farjo, Ayad A.;Goins, Kenneth M.;Mullinnix, Connie;Burris, Terry E.;Johnson, Susan;Kerns, Dawn;Powell, Jenni;Swenson, Portia;Shriver, Peter A.;Williams, Dennis;Perry, Kelly;Wells, Monica;Self, Cynthia A.;Wilbanks, Garth A.;Chute, Courtney;Hart, Cheryl;Chuck, Roy S.;Gaster, Ronald N.;Bradley, Michael;Cohen, Andre;Eghbali, Kouroush;Farid, Marjan;Garg, Sumit;Grijalva, Jeff;Lomazow, Whitney;Kielty, David W.;Davis, Garvin H.;Bourg, J. Mike;Van Meter, Woodford S.;webb, Jan;Smith, Patricia W.;Bradshaw, Robbin;Mewborn, Tineta;Sanchez, Jorge;Schaeffer, Alan R.;Owens, Chasity;Price, Charlisha;Cohen, Elisabeth J.;Laibson, Peter R.;Rapuano, Christopher J.;Gardiner, Andrea;Baratz, Keith H.;Halpern, Barton L.;Pavilack, Mark A.;Gallagher, Shawn;Rosen, Gerald B.;Doughman, Donald J.;Kaufman, Stephen C.;Cook, Sally;Holleschau, Ann;Perl, Theodore;Pak, Soo Mee;Fornelos, Angelina;Cowden, John W.;Perlman, Elliot M.;Cozzo, Joanie;Gallagher-Sylvia, Margaret;Olson, Lance E.;Skoog, Erik D.;Dobbs, Elaine;Gruzensky, William D.;Groos, Erich B., Jr.;Alexander, Denise;Mifflin, Mark D.;Lundergan, Maureen K.;Harrison, Deborah;Berger, Steven T.;Hyszczak, Sandy;Solomon, Kerry D.;Bradham, Carol;Dennis, Richard F.;Rubenstein, Jonathan B.;Levine, Sarah;Khan, Heena;Sheth, Nisha;Voskull-Marre, Denise;Kostick, Alexandra M. P.;Santander, Samuel H.;Roth, Allen S.;Bealer, Laura A.;Macy, Jonathan I.;O'Day, David G.;Maynard, Linda;Terry, Mark A.;Sossi, Nunzio P.;Walter, Keith A.;Fish, Joan;Johnston, Florence M.;Mavin, Kyle L.;McCoy, Kristen E.;O'Keefe, Michael B.;Cole, Gerald J.;Johnston, Diane F.;Jones, Mark A.;Farazdaghi, Sameera M.;Walunas, Elizabeth N.;Montoya, Monty M.;Iliakis, Bernie;McDonald, Rick D.;Ostermiller, Misty L.;Saltwick, Cathy E.;Woody, Jason K.;Weaver, Mark H.;Christ, Michael J.;Gross, Mark B.;Engel, Carol R.;Dale, Raylene A.;Hackl, Stephanie K.;Henriksen, Elena J.;Kalmoe, Kathryn J.;Larson, Jennifer M.;Malling, Jackie V.;Philippy, Brian J.;Hayes, Sue M.;Lytle, Robert E.;Rechtshaffen, David A.;Varnum, Bruce;Angel, Erin B.;Durell, Matt D.;Williams, Teresa R.;Janssen, Susan V.;Kraus, Brian E.;McLain, Marcy B.;Rossi, Jackie A.;Heck, Ellen L.;Hayes, Marilyn S.;Davis, Gregory C.;Chavez, Tara L.;Oswald, Lori D.;Ruiz, Noreen B.;Penta, Jeffrey G.;Dietz, Wayne E.;Nary, Jennifer L.;Sheriff, Kenneth R.;Driver, Nancy C.;Faircloth, William J.;Williams, Paul E.;Weber, Kurt;Barker, Jerry W.;Bridges, Donna M.;Soper, Mark;Allen, Betsy;Wright, Samantha J.;Martin, James R.;Watson, Anne J.;McDonough, Greg;Beilby, Kristel D.;Fraser, Linda K.;Sharpe, Tammi S.;Arffa, Robert C.;Tramber, Michael A.;Crow, Barbara L.;Fisher, Matthew M.;Stoeger, Chris G.;Jacobs, Edmund;Filbin, Michael P.;Mather, James I.;McGriff, Christopher M.;Meinecke, Eric E.;Mason, Patricia J.;Locke, Garret D.;Reiter, Janice F.;Korroch, David E.;Thomas, Penelope M.;Lange, Wayne A.;Moore, Rosemary F.;Williams, Lee J.;Friedhoff, Yvette D.;Walkenbach, Ronald J.;Glover, Jennifer E.;Kafton, Brenda A.;Lage, Kraig J.;Horn, Brenda S.;Bottoms, H. Tommy;Kerns, Ellen R.;Jessen, Raymond;Dennis, William H.;Beck, Roy W.;Gal, Robin L.;Kollman, Craig;Raghinaru, Dan;Powe, Alandra;Ruedy, Katrina J.;Lester, Lee Anne;Strayer, Heidi J.;Mares, Shelly T.;Evans, Amber;Parrimon, Yazandra A.;Gray, Michael;Lass, Jonathan H.;Benetz, Beth Ann;Burke, Stephanie;Edwards, Shannon;Gentile, Carmella;Karpinecz, Lori;Madere, Mark;Redford, Maryann;Cotch, Mary Frances;Fisher, Marian;Bourne, William;Redford, Maryann;Fishman, Rabbi Samuel;Foulks, Gary;Musch, David C.;Holland, Edward J.;Mannis, Mark J.;Cotch, Mary Frances;Dunn, Steven;Heck, Ellen;Johnston, Florence;Lass, Jonathan H.;Lindquist, Thomas;Montoya, Monty M.;Redford, Maryann;Sugar, Alan;Sugar, Joel;Woody, Jason
角膜供体研究(CDS)表明，供体年龄不是大多数内皮疾病穿透性角膜成形术存活率的一个因素。二次分析证实了手术指征和青光眼的存在对10年后预后的重要性。目的探讨CDS供受者因素与角膜移植物存活率的关系。多中心前瞻性、双盲、对照临床试验，来自80个临床站点的105名外科医生登记参加，43个眼库提供角膜。1090名接受角膜移植的中等危险情况的受试者，主要是Fuchs营养不良或人工晶状体/无晶状体角膜水肿症(PACE)的捐赠者，来自66岁或≥66岁的捐赠者，被分配到捐赠者的年龄。手术和术后护理均按外科医生的常规程序进行。受试者被跟踪了长达12年的时间。移植失败定义为连续3个月的再移植或角膜混浊。PACE患者的10年移植物失败率高于Fuchs营养不良患者(37%比20%，p<；0.001)，以及在穿透性角膜移植前有青光眼病史的患者，特别是既往有青光眼手术经历的患者(58%有青光眼手术和手术时用药，而22%没有青光眼病史，p<；0.001)。在年龄较大(p=0.04)、非裔美国人(p=0.11)或有吸烟史(p=0.02)的受者中，移植失败有增加的趋势。术后6个月、1年和5年的内皮细胞密度较低和角膜厚度较高与随后的植片失败有关(p=0.04tolt；0.001)。大多数穿透性角膜移植治疗Fuchs营养不良或PACE在10年后仍然清晰。对于那些有PACE和青光眼病史的人来说，失败的风险更大。角膜移植术后随访过程中的ECD和CT测量与失败的风险相关。然而，即使在5年时有非常低的ECD和高CT，大多数角膜在10年时仍然是透明的。
The Cornea Donor Study (CDS) showed that donor age is not a factor in survival of most penetrating keratoplasties for endothelial disease. Secondary analyses confirm the importance of surgical indication and presence of glaucoma in outcomes at 10 years. To assess the relationship between donor and recipient factors and corneal graft survival in the CDS. Multi-center prospective, double-masked, controlled clinical trial 105 surgeons from eighty clinical sites enrolled participants and forty-three eye banks provided corneas. 1090 subjects undergoing corneal transplantation for a moderate risk condition, principally Fuchs’ dystrophy or pseudophakic/aphakic corneal edema (PACE) Corneas from donors <66 years or ≥ 66 years were assigned, double-masked to donor age. Surgery and post-operative care were performed according to surgeons’ usual routines. Subjects were followed for up to twelve years. Graft failure defined as a regraft or a cloudy cornea for 3 consecutive months. The 10-year graft failure rate was higher in cases with PACE than with Fuchs’ dystrophy (37% versus 20%, p < 0.001) and in cases with a history of glaucoma prior to penetrating keratoplasty, particularly with prior glaucoma surgery (58% with prior glaucoma surgery and medications at time of surgery versus 22% with no history of glaucoma, p<0.001). There were trends towards increased graft failure in recipients who were older (p=0.04), African-American (p=0.11), or had a smoking history (p=0.02). Lower endothelial cell density (ECD) and higher corneal thickness (CT) at 6 months, 1 year, and 5 years were associated with subsequent graft failure (p=0.04 to <0.001). Most penetrating corneal grafts for Fuchs’ dystrophy or PACE remain clear at 10 years. The risk of failure is greater for those with PACE and when there is a history of glaucoma. ECD and CT measurements during the course of post-keratoplasty follow up are associated with risk of failure. However, even with very low ECD and high CT at 5 years, most corneas remain clear at 10 years.
登录
查看更多内容
影响因子：
13.7
作者：
Gal, Robin L.;Dontchev, Mariya;Verdier, David D.
通讯作者：
Verdier, David D.
影响因子：
2.8
作者：
Verdier DD;Sugar A;Baratz K;Beck R;Dontchev M;Dunn S;Gal RL;Holland EJ;Kollman C;Lass JH;Mannis MJ;Penta J;Cornea Donor Study Investigator Group
通讯作者：
Cornea Donor Study Investigator Group
影响因子：
13.7
作者：
Lass, Jonathan H.;Gal, Robin L.;Verdier, David D.
通讯作者：
Verdier, David D.
影响因子：
2
作者：
Benetz, BA;Gal, RL;Lass, JH
通讯作者：
Lass, JH
影响因子：
13.7
作者：
Mannis, Mark J.;Holland, Edward J.;Beck, Roy W.
通讯作者：
Beck, Roy W.