Atherosclerosis and thrombosis: insights from large animal models.
Atherosclerosis and thrombosis: insights from large animal models.
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DOI：
10.1155/2011/907575
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发表时间：
2011
影响因子：
--
通讯作者：
Badimon L
中科院分区：
文献类型：
--
作者：
Vilahur G;Padro T;Badimon L
动脉粥样硬化及其血栓并发症是造成大量死亡的原因。体外、离体和体内实验方法的结合在很大程度上有助于更好地理解动脉粥样硬化血栓形成过程的机制。事实上，不同的动物模型已经在动脉粥样硬化和血栓形成研究中实施，以便为已经在分离细胞和蛋白质研究中概述的机制提供新的见解。然而，尽管没有模型完全模仿人类病理，但大型动物模型已证明更适合翻译为人类。事实上，从小鼠到人类的直接转化应该谨慎对待，因为物种相关的差异已经得到了充分的报道。本文概述了现有的动脉粥样硬化样动物模型，特别关注血栓形成和动脉粥样硬化的大型动物模型，并检查了它们在转化研究目的中的适用性，并强调了与人类相关的物种差异。
Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well-reported species-related differences. This paper provides an overview of the available atherothrombotic-like animal models, with a particular focus on large animal models of thrombosis and atherosclerosis, and examines their applicability for translational research purposes as well as highlights species-related differences with humans.
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DOI：
10.1161/01.atv.6.3.312
发表时间：
1986-05-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
BADIMON, L;BADIMON, JJ;FUSTER, V
通讯作者：
FUSTER, V
影响因子：
3.1
作者：
BAUMGARTNER, HR
通讯作者：
BAUMGARTNER, HR
影响因子：
37.8
作者：
Botnar, RM;Perez, AS;Johnstone, MT
通讯作者：
Johnstone, MT
影响因子：
37.8
作者：
Alt, E;Haehnel, I;Schömig, A
通讯作者：
Schömig, A
影响因子：
37.8
作者：
BADIMON, L;BADIMON, JJ;FUSTER, V
通讯作者：
FUSTER, V