Non-canonical odor coding in the mosquito.
Non-canonical odor coding in the mosquito.
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DOI：
10.1016/j.cell.2022.07.024
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发表时间：
2022-08-18
期刊：
影响因子：
64.5
通讯作者：
Younger, Meg A.
中科院分区：
文献类型：
--
作者：
Herre, Margaret;Goldman, Olivia, V;Lu, Tzu-Chiao;Caballero-Vidal, Gabriela;Qi, Yanyan;Gilbert, Zachary N.;Gong, Zhongyan;Morita, Takeshi;Rahiel, Saher;Ghaninia, Majid;Ignell, Rickard;Matthews, Benjamin J.;Li, Hongjie;Vosshall, Leslie B.;Younger, Meg A.
Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor and carbon dioxide, which they detect using ionotropic chemosensory receptors encoded by three large multi-gene families. Genetic mutations that disrupt the olfactory system have modest effects on human attraction, suggesting redundancy in odor coding. The canonical view is that olfactory sensory neurons each express a single chemosensory receptor that defines its ligand selectivity. We discovered that Ae. aegypti uses a different organizational principle, with many neurons co-expressing multiple chemosensory receptor genes. In vivo electrophysiology demonstrates that the broad ligand-sensitivity of mosquito olfactory neurons depends on this non-canonical co-expression. The redundancy afforded by an olfactory system in which neurons co-express multiple chemosensory receptors may increase the robustness of the mosquito olfactory system and explain our long-standing inability to disrupt the detection of humans by mosquitoes. Humans produce a complex blend of odor cues that attract female mosquitoes, and these cues are typically detected by olfactory neurons expressing a single receptor. In female Aedes aegypti mosquitos, however, many of these neurons co-express multiple chemosensory receptors directly affecting mosquito behavior and challenging the canonical one-receptor-to-one-neuron organization.
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影响因子：
9.8
作者：
Ebrahim SA;Dweck HK;Stökl J;Hofferberth JE;Trona F;Weniger K;Rybak J;Seki Y;Stensmyr MC;Sachse S;Hansson BS;Knaden M
通讯作者：
Knaden M
人类的影响塑造了埃及埃及，登革热和黄热病蚊子的历史和最新进化。
DOI：
10.1111/evo.12281
发表时间：
2014-02
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Brown JE;Evans BR;Zheng W;Obas V;Barrera-Martinez L;Egizi A;Zhao H;Caccone A;Powell JR
通讯作者：
Powell JR
影响因子：
9.8
作者：
Benton, Richard;Sachse, Silke;Michnick, Stephen W;Vosshall, Leslie B
通讯作者：
Vosshall, Leslie B
影响因子：
7.7
作者：
Basrur NS;De Obaldia ME;Morita T;Herre M;von Heynitz RK;Tsitohay YN;Vosshall LB
通讯作者：
Vosshall LB
影响因子：
2.6
作者：
Bohbot, J.;Pitts, R. J.;Zwiebel, L. J.
通讯作者：
Zwiebel, L. J.