Current treatment options for recurrent nasopharyngeal cancer.

Current treatment options for recurrent nasopharyngeal cancer.
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DOI:
10.1007/s00405-010-1385-x
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发表时间:
2010-12
期刊:
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
影响因子:
--
通讯作者:
Ferlito A
Ferlito A
中科院分区:
其他
文献类型:
--
作者:
Suárez C;Rodrigo JP;Rinaldo A;Langendijk JA;Shaha AR;Ferlito A

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近十年来,鼻咽癌(NPC)的局部控制率显着提高。然而,局部复发仍然是晚期死亡和发病的主要原因,局部失败的治疗仍然是鼻咽癌的一个具有挑战性的问题。局部复发性鼻咽癌的最佳挽救治疗仍有待确定。这些选择包括单独或不同组合的近距离放射治疗、外部放射治疗、立体定向放射外科和鼻咽切除术。在本文中,我们将讨论抢救局部复发性 NPC 的不同选择。单独使用放疗或与其他治疗方式相结合以及手术对局部复发性鼻咽癌进行再治疗,可以使相当大比例的患者获得长期局部控制和生存。对于采用外部放射治疗、近距离放射治疗或立体定向放射外科治疗的小体积复发性肿瘤(T1-T2),已报道了与手术获得的结果相当的结果。相比之下,晚期局部复发性鼻咽癌的治疗结果通常比再放疗更令人满意,手术(有或没有术后放疗)。
Loco-regional control rate of nasopharyngeal carcinoma (NPC) has improved significantly in the past decade. However, local recurrence still represents a major cause of mortality and morbidity in advanced stages, and management of local failure remains a challenging issue in NPC. The best salvage treatment for local recurrent NPC remains to be determined. The options include brachytherapy, external radiotherapy, stereotactic radiosurgery, and nasopharyngectomy, either alone or in different combinations. In this article we will discuss the different options for salvage of locally recurrent NPC. Retreatment of locally recurrent NPC using radiotherapy, alone or in combination with other treatment modalities, as well as surgery, can result in long-term local control and survival in a substantial proportion of patients. For small-volume recurrent tumors (T1–T2) treated with external radiotherapy, brachytherapy or stereotactic radiosurgery, comparable results to those obtained with surgery have been reported. In contrast, treatment results of advanced-stage locally recurrent NPC are generally more satisfactory with surgery (with or without postoperative radiotherapy) than with reirradiation.
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