3D quantification of mandibular asymmetry using the SPHARM-PDM tool box.

3D quantification of mandibular asymmetry using the SPHARM-PDM tool box.
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DOI:
10.1007/s11548-011-0665-2
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发表时间:
2012-03
影响因子:
3
通讯作者:
Tyndall, Donald
Tyndall, Donald
中科院分区:
工程技术3区
文献类型:
--
作者:
AlHadidi, Abeer;Cevidanes, Lucia H.;Paniagua, Beatriz;Cook, Richard;Festy, Frederic;Tyndall, Donald

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通过定量的形态建模和分析,可以提高正颌外科患者下颌骨不对称的前期诊断水平。北卡罗来纳大学SPHARM-PDM(北卡罗来纳大学球谐和点分布模型)工具箱被应用于一组患者,并对结果进行评估。通过分割,从队列中每个患者的CBCT扫描中构建三维(3D)虚拟表面模型。矢状任意平面上的镜像用于翻转每个图像的左侧和右侧。在颅底上使用基于体素的自动配准来对准体积及其镜面以进行比较。用SPHARM-PDM软件计算各半下颌骨和对侧镜面的相应模型。使用Procrstes分析来评估每对模型之间的差异以评估不对称性。通过计算每个半下颌骨(左侧和右侧)与对侧镜子之间的相应表面距离,对下颌不对称进行定位和量化。在基于右侧和左侧镜像的下颌不对称评估的替代者中,没有统计学上的显著差异。这些替代物是每个半下颌与对侧的镜子在3个空间平面上的旋转和平移差异(6个自由度输出的Procrstes配准绝对值)。每个半下颌骨与对侧镜面之间的绝对距离图和带符号距离图定位并量化了每个患者的不对称诊断区域。8%的病例表现为下颌骨不对称,17.8%的病例表现为下颌升支和下颌体部的不对称,74.2%的病例表现为下颌骨的整体形态和位置不对称。下颌骨不对称的三维诊断揭示了下颌骨形态成分的复杂受累和这种临床情况的异质性。SPARM-PDM在下颌骨不对称的个体化诊断和量化方面具有广阔的应用前景。
Pretreatment diagnosis of mandibular asymmetry in orthognathic surgery patients can be improved by quantitative shape modeling and analysis. The UNC SPHARM-PDM (University of North Carolina Spherical Harmonics—Point Distribution Model) toolbox was applied to a cohort of patients and the results were evaluated. Three-dimensional (3D) virtual surface models are constructed from CBCT scans of each patient in the cohort by segmentation. Mirroring on a sagittal arbitrary plane is used to flip the left and right sides of each image. An automatic voxel-based registration on the cranial base is used to align the volume and its mirror for comparison. SPHARM-PDM is used to compute correspondent models for each hemimandible and the mirror of the contralateral side. Procrustes analysis was used to evaluate discrepancies between each pair of models to assess asymmetry. Mandibular asymmetry was also located and quantified by computing corresponding surface distances between each hemimandible (left and right sides) and the mirror of the contralateral side. There were no statistically significant differences in surrogates for mandibular asymmetry assessment based on right or the left side mirroring. Those surrogates are the rotational and translational differences between each hemimandible and the mirror of the contralateral side in 3 planes of space (the absolute values of Procrustes registration output in 6 degrees of freedom). Absolute and signed distance maps between each hemimandible and the mirror of the contralateral side located and quantified areas of asymmetry diagnosis for each patient. Even though mandibular condyle asymmetry was observed in 8% of the cases and mandibular asymmetry along areas of the ramus and mandibular corpus was noted in 17.8% of the cases, the remaining 74.2% showed generalized morphological and positional asymmetry at the condyle, the ramus and mandibular corpus. Three-dimensional diagnosis of mandibular asymmetry revealed the complex involvement of morphological components of the mandible and the heterogeneous nature of this clinical condition. SPHARM-PDM has a promising role in the individual diagnosis and quantification of mandibular asymmetry.
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